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GATA2 mitotic bookm...
GATA2 mitotic bookmarking is required for definitive haematopoiesis
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- Silvério-Alves, Rita (author)
- Lund University,Lunds universitet,Cellulär omprogrammering i hematopoes och immunitet,Forskargrupper vid Lunds universitet,Cell Reprogramming in Hematopoiesis and Immunity,Lund University Research Groups,University of Coimbra
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- Kurochkin, Ilia (author)
- Lund University,Lunds universitet,Cellulär omprogrammering i hematopoes och immunitet,Forskargrupper vid Lunds universitet,Cell Reprogramming in Hematopoiesis and Immunity,Lund University Research Groups
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- Rydström, Anna (author)
- Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine
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- Vazquez echegaray, Camila (author)
- Lund University,Lunds universitet,Cellulär omprogrammering i hematopoes och immunitet,Forskargrupper vid Lunds universitet,Cell Reprogramming in Hematopoiesis and Immunity,Lund University Research Groups
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- Haider, Jakob (author)
- Lund University,Lunds universitet,Cellulär omprogrammering i hematopoes och immunitet,Forskargrupper vid Lunds universitet,Cell Reprogramming in Hematopoiesis and Immunity,Lund University Research Groups
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- Nicholls, Matthew (author)
- University of Oxford
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- Rode, Christina (author)
- University of Oxford
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- Thelaus, Louise (author)
- Lund University,Lunds universitet,Translationell Sepsisforskning,Forskargrupper vid Lunds universitet,Heparinbindande protein inom thoraxkirurgi,Translational Sepsis research,Lund University Research Groups,Heparin bindning protein in cardiothoracic surgery
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- Lindgren, Aida Yifter (author)
- Lund University,Lunds universitet,Cancerimmunologi, Malmö,Forskargrupper vid Lunds universitet,Cancer Immunology, Malmö,Lund University Research Groups
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- Ferreira, Alexandra Gabriela (author)
- Lund University,Lunds universitet,Cellulär omprogrammering i hematopoes och immunitet,Forskargrupper vid Lunds universitet,Cell Reprogramming in Hematopoiesis and Immunity,Lund University Research Groups,University of Coimbra
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- Brandão, Rafael (author)
- University of Copenhagen
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- Larsson, Jonas (author)
- Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,WCMM- Wallenberg center för molekylär medicinsk forskning,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,WCMM-Wallenberg Centre for Molecular Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- De bruijn, Marella F. T. R. (author)
- University of Oxford
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- Martin-Gonzalez, Javier (author)
- University of Copenhagen
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- Pereira, Filipe (author)
- Lund University,Lunds universitet,Cellulär omprogrammering i hematopoes och immunitet,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cell Reprogramming in Hematopoiesis and Immunity,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,University of Coimbra
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Nature Communications. - 2041-1723. ; 14:1
- Related links:
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- In mitosis, most transcription factors detach from chromatin, but some are retained and bookmark genomic sites. Mitotic bookmarking has been implicated in lineage inheritance, pluripotency and reprogramming. However, the biological significance of this mechanism in vivo remains unclear. Here, we address mitotic retention of the hemogenic factors GATA2, GFI1B and FOS during haematopoietic specification. We show that GATA2 remains bound to chromatin throughout mitosis, in contrast to GFI1B and FOS, via C-terminal zinc finger-mediated DNA binding. GATA2 bookmarks a subset of its interphase targets that are co-enriched for RUNX1 and other regulators of definitive haematopoiesis. Remarkably, homozygous mice harbouring the cyclin B1 mitosis degradation domain upstream Gata2 partially phenocopy knockout mice. Degradation of GATA2 at mitotic exit abolishes definitive haematopoiesis at aorta-gonad-mesonephros, placenta and foetal liver, but does not impair yolk sac haematopoiesis. Our findings implicate GATA2-mediated mitotic bookmarking as critical for definitive haematopoiesis and highlight a dependency on bookmarkers for lineage commitment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Silvério-Alves, ...
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Kurochkin, Ilia
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Rydström, Anna
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Vazquez echegara ...
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Haider, Jakob
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Nicholls, Matthe ...
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show more...
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Rode, Christina
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Thelaus, Louise
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Lindgren, Aida Y ...
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Ferreira, Alexan ...
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Brandão, Rafael
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Larsson, Jonas
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De bruijn, Marel ...
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Martin-Gonzalez, ...
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Pereira, Filipe
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Nature Communica ...
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Lund University