Search: onr:"swepub:oai:lup.lub.lu.se:ddb83ddc-54c8-4cd8-ace6-3e9617f3d1f3" >
Altered d-glucose i...
Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer's disease detected by dynamic glucose-enhanced MRI
-
- Huang, Jianpan (author)
- City University of Hong Kong
-
- van Zijl, Peter C M (author)
- Kennedy Krieger Institute
-
- Han, Xiongqi (author)
- City University of Hong Kong
-
show more...
-
- Dong, Celia M (author)
- University of Hong Kong
-
- Cheng, Gerald W Y (author)
- Hong Kong Polytechnic University
-
- Tse, Kai-Hei (author)
- Hong Kong Polytechnic University
-
- Knutsson, Linda (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital,Johns Hopkins University School of Medicine
-
- Chen, Lin (author)
- Kennedy Krieger Institute
-
- Lai, Joseph H C (author)
- City University of Hong Kong
-
- Wu, Ed X (author)
- University of Hong Kong
-
- Xu, Jiadi (author)
- Kennedy Krieger Institute
-
- Chan, Kannie W Y (author)
- City University of Hong Kong
-
show less...
-
(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2020
- 2020
- English.
-
In: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 6:20
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://advances.sci...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI can identify altered glucose uptake and clearance in young AD mice upon the emergence of amyloid plaques. DGE MRI of brain parenchyma and CSF has potential for early AD stratification, especially at 3T clinical field strength MRI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Huang, Jianpan
-
van Zijl, Peter ...
-
Han, Xiongqi
-
Dong, Celia M
-
Cheng, Gerald W ...
-
Tse, Kai-Hei
-
show more...
-
Knutsson, Linda
-
Chen, Lin
-
Lai, Joseph H C
-
Wu, Ed X
-
Xu, Jiadi
-
Chan, Kannie W Y
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Physical Science ...
-
and Other Physics To ...
- Articles in the publication
-
Science Advances
- By the university
-
Lund University