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Comparing ATN-T des...
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Provost, KarineUniversity of California, San Francisco
(author)
Comparing ATN-T designation by tau PET visual reads, tau PET quantification, and CSF PTau181 across three cohorts
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-01-04
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Springer Science and Business Media LLC,2021
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13 s.
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LIBRIS-ID:oai:lup.lub.lu.se:ddca0f01-6f18-4a61-8e50-491228956342
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https://lup.lub.lu.se/record/ddca0f01-6f18-4a61-8e50-491228956342URI
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https://doi.org/10.1007/s00259-020-05152-8DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Purpose: To compare rates of tau biomarker positivity (T-status) per the 2018 Alzheimer’s Disease (AD) Research Framework derived from [18F]flortaucipir (FTP) PET visual assessment, FTP quantification, and cerebrospinal fluid (CSF) phosphorylated Tau-181 (PTau181). Methods: We included 351 subjects with varying clinical diagnoses from three cohorts with available FTP PET and CSF PTau181 within 18 months. T-status was derived from (1) FTP visual assessment by two blinded raters; (2) FTP standardized uptake value ratio (SUVR) quantification from a temporal meta-ROI (threshold: SUVR ≥1.27); and (3) Elecsys® Phospho-Tau (181P) CSF (Roche Diagnostics) concentrations (threshold: PTau181 ≥ 24.5 pg/mL). Results: FTP visual reads yielded the highest rates of T+, while T+ by SUVR increased progressively from cognitively normal (CN) through mild cognitive impairment (MCI) and AD dementia. T+ designation by CSF PTau181 was intermediate between FTP visual reads and SUVR values in CN, similar to SUVR in MCI, and lower in AD dementia. Concordance in T-status between modality pairs ranged from 68 to 76% and varied by clinical diagnosis, being highest in patients with AD dementia. In discriminating Aβ + MCI and AD subjects from healthy controls and non-AD participants, FTP visual assessment was most sensitive (0.96) but least specific (0.60). Specificity was highest with FTP SUVR (0.91) with sensitivity of 0.89. Sensitivity (0.73) and specificity (0.72) were balanced for PTau181. Conclusion: The choice of tau biomarker may differ by disease stage and research goals that seek to maximize sensitivity or specificity. Visual interpretations of tau PET enhance sensitivity compared to quantification alone, particularly in early disease stages.
Subject headings and genre
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Iaccarino, LeonardoUniversity of California, San Francisco
(author)
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Soleimani-Meigooni, David N.Lawrence Berkeley National Laboratory,University of California, San Francisco
(author)
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Baker, SuzanneLawrence Berkeley National Laboratory
(author)
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Edwards, LaurenUniversity of California, San Francisco
(author)
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Eichenlaub, UdoRoche Diagnostics, Germany
(author)
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-ohn
(author)
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Jagust, WilliamUniversity of California, Berkeley,Lawrence Berkeley National Laboratory
(author)
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Janabi, MustafaLawrence Berkeley National Laboratory
(author)
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La Joie, RenaudUniversity of California, San Francisco
(author)
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Lesman-Segev, OritUniversity of California, San Francisco
(author)
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Mellinger, Taylor J.University of California, San Francisco
(author)
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Miller, Bruce L.University of California, San Francisco
(author)
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Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam(Swepub:lu)ri1513os
(author)
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Pham, JulieUniversity of California, San Francisco
(author)
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Smith, RubenLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-rsm
(author)
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Sonni, IdaUniversity of California, Los Angeles,Lawrence Berkeley National Laboratory
(author)
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Strom, AmeliaUniversity of California, San Francisco
(author)
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Mattsson-Carlgren, NiklasLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Clinical Memory Research,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-nmn
(author)
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Rabinovici, Gil D.Lawrence Berkeley National Laboratory,University of California, Berkeley,University of California, San Francisco
(author)
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University of California, San FranciscoLawrence Berkeley National Laboratory
(creator_code:org_t)
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Alzheimer's Disease Neuroimaging Initiative
Related titles
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In:European Journal of Nuclear Medicine and Molecular Imaging: Springer Science and Business Media LLC48:7, s. 2259-22711619-70701619-7089
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Provost, Karine
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Iaccarino, Leona ...
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Soleimani-Meigoo ...
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Baker, Suzanne
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Edwards, Lauren
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Eichenlaub, Udo
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Hansson, Oskar
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Jagust, William
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Janabi, Mustafa
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La Joie, Renaud
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Lesman-Segev, Or ...
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Mellinger, Taylo ...
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Miller, Bruce L.
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Ossenkoppele, Ri ...
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Pham, Julie
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Smith, Ruben
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Sonni, Ida
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Strom, Amelia
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Mattsson-Carlgre ...
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Rabinovici, Gil ...
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- MEDICAL AND HEALTH SCIENCES
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