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Outcomes for reduce...
Outcomes for reduced-intensity allogeneic transplantation for multiple myeloma: an analysis of prognostic factors from the Chronic Leukaemia Working Party of the EBMT
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Crawley, C (author)
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Lalancette, M (author)
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Szydlo, R (author)
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Gilleece, M (author)
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Peggs, K (author)
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Mackinnon, S (author)
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- Juliusson, Gunnar (author)
- Östergötlands Läns Landsting,Linköpings universitet,Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Hälsouniversitetet,Onkologi,Hematologiska kliniken US
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- Ahlberg, Lucia (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Hematologiska kliniken US
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Nagler, A (author)
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Shimoni, A (author)
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Sureda, A (author)
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Boiron, JM (author)
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Einsele, H (author)
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Chopra, R (author)
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Carella, A (author)
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Cavenagh, J (author)
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Gratwohl, A (author)
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Garban, F (author)
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Zander, A (author)
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Bjorkstrand, B (author)
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Niederwieser, D (author)
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- Gahrton, G (author)
- Karolinska Institutet
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Apperley, JF (author)
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(creator_code:org_t)
- American Society of Hematology, 2005
- 2005
- English.
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 105:11, s. 4532-4539
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https://lup.lub.lu.s...
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Abstract
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- We report the outcome of 229 patients who received an allograft for myeloma with reduced-intensity conditioning (RIC) regimens from 33 centers within the European Group for Blood and Marrow Transplantation (EBMT). The median age was 52 years and 64% were male. Conditioning regimens were heterogeneous, but most were fludarabine based and T cell depleted with antithymocyte globulin or alemtuzumab. Transplantation-related mortality (TRIM) at 1 year was 22%. The 3-year overall survival (OS) and progression-free survival (PFS) were 41% and 21 %, respectively. Adverse OS was associated with chemoresistant disease (relative risk [RR], 2.9), more than 1 prior transplantation (RR, 2.0), and male patients with female donors (FIR, 1.45). Adverse PFS was associated with chemoresistance (RR, 2.4) and alemtuzumab (RR, 1.8). TRM was increased with female-to-male donation (RR, 2.5) and transplantation more than 1 year from diagnosis (RR, 2.3). Grades II to IV acute graft-versus-host disease (aGvHD) occurred in 31%. Chronic GvHD was associated with better OS and PFS and were 84% and 46% for limited, 58% and 30% for extensive, and 29% and 12% in its absence suggesting that a graft-versus-myeloma effect is important. While RIC is feasible, heavily pretreated patients and patients with progressive disease do not benefit.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- MEDICINE
Publication and Content Type
- art (subject category)
- ref (subject category)
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Blood
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To the university's database
- By the author/editor
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Crawley, C
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Lalancette, M
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Szydlo, R
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Gilleece, M
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Peggs, K
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Mackinnon, S
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show more...
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Juliusson, Gunna ...
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Ahlberg, Lucia
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Nagler, A
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Shimoni, A
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Sureda, A
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Boiron, JM
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Einsele, H
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Chopra, R
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Carella, A
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Cavenagh, J
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Gratwohl, A
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Garban, F
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Zander, A
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Bjorkstrand, B
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Niederwieser, D
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Gahrton, G
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Apperley, JF
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood
- By the university
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Lund University
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Karolinska Institutet
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Linköping University