onr:"swepub:oai:lup.lub.lu.se:de3e0bc9-0026-48ae-aae6-08424b7734a7"
Search: onr:"swepub:oai:lup.lub.lu.se:de3e0bc9-0026-48ae-aae6-08424b7734a7" > Leukemic blasts are...
- 1 of 1
- Previous record
- Next record
- To hitlist
Leukemic blasts are present at low levels in spinal fluid in one-third of childhood acute lymphoblastic leukemia cases
-
- Levinsen, Mette (author)
- Copenhagen University Hospital
-
- Marquart, Hanne V. (author)
- Copenhagen University Hospital
-
- Groth-Pedersen, Line (author)
- Copenhagen University Hospital
- show more...
- show less...
- (creator_code:org_t)
- 2016-07-22
- 2016
- English 8 s.
- In: Pediatric Blood & Cancer. - : Wiley. - 1545-5009 .- 1545-5017. ; 63:11, s. 1935-1942
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Background: Central nervous system (CNS) involvement is associated with relapse in childhood acute lymphoblastic leukemia (ALL) and is a diagnostic challenge. Procedure: In a Nordic/Baltic prospective study, we assessed centralized flow cytometry (FCM) of locally fixed cerebrospinal fluid (CSF) samples versus local conventional cytospin-based cytology (CC) for detecting leukemic cells and evaluating kinetics of elimination of leukemic cells in CSF. Results: Among 300 patients with newly diagnosed ALL, 87 (29%) had CSF involvement by FCM, while CC was positive in 30 (10%) of 299 patients with available CC data (P < 0.001). Patients with FCM+/CC+ had higher CSF leukemic blast counts compared to patients positive by FCM only (medians: 0.10 vs. 0.017 leukemic blasts/μl, P = 0.006). Patients positive by FCM had higher white blood cell counts in peripheral blood than patients negative by FCM (medians: 45 × 109/l vs. 10 × 109/l, P < 0.001), were younger (medians: 3 years vs. 4 years, P = 0.03), and more frequently had T-cell ALL (18/87 vs. 16/213, P = 0.001). At treatment day 15, five of 52 patients (10%) who had CSF positive by FCM at diagnosis remained so despite at least two doses of weekly intrathecal chemotherapy. Conclusions: Longer follow-up is needed to clarify whether FCM positivity has prognostic significance and is an indicator for intensified CNS-directed therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- acute
- ALL
- CSF leukemia
- leukemias
- minimal residual disease
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- Pediatric Blood & Cancer (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Levinsen, Mette
- Marquart, Hanne ...
- Groth-Pedersen, ...
- Abrahamsson, Jon ...
- Albertsen, Birgi ...
- Andersen, Mette ...
- show more...
- Frandsen, Thomas ...
- Harila-Saari, Ar ...
- Pronk, Cornelis
- Ulvmoen, Aina
- Vaitkevičienė, G ...
- Lähteenmäki, Päi ...
- Niinimäki, Riitt ...
- Taskinen, Mervi
- Jeppesen, Maria
- Schmiegelow, Kje ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Hematology
- Articles in the publication
- Pediatric Blood ...
- By the university
- Lund University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
