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- Goncalves, IsabelLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - translationella studier,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Cardiovascular Research - Translational Studies (author)
Activation of calpain-1 in human carotid artery atherosclerotic lesions
- Article/chapterEnglish2009
Publisher, publication year, extent ...
- 2009-06-18
- Springer Science and Business Media LLC,2009
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- LIBRIS-ID:oai:lup.lub.lu.se:deebbc7d-884a-4473-831c-0376e64efd9e
- https://lup.lub.lu.se/record/1462817URI
- https://doi.org/10.1186/1471-2261-9-26DOI
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- Language:English
- Summary in:English
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- Background: In a previous study, we observed that oxidized low-density lipoprotein-induced death of endothelial cells was calpain-1-dependent. The purpose of the present paper was to study the possible activation of calpain in human carotid plaques, and to compare calpain activity in the plaques from symptomatic patients with those obtained from patients without symptoms. Methods: Human atherosclerotic carotid plaques (n = 29, 12 associated with symptoms) were removed by endarterectomy. Calpain activity and apoptosis were detected by performing immunohistochemical analysis and TUNEL assay on human carotid plaque sections. An antibody specific for calpain-proteolyzed alpha-fodrin was used on western blots. Results: We found that calpain was activated in all the plaques and calpain activity colocalized with apoptotic cell death. Our observation of autoproteolytic cleavage of the 80 kDa subunit of calpain-1 provided further evidence for enzyme activity in the plaque samples. When calpain activity was quantified, we found that plaques from symptomatic patients displayed significantly lower calpain activity compared with asymptomatic plaques. Conclusion: These novel results suggest that calpain-1 is commonly active in carotid artery atherosclerotic plaques, and that calpain activity is colocalized with cell death and inversely associated with symptoms.
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- Nitulescu, MihaelaLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)medf-mni (author)
- Saido, Takaomi C. (author)
- Dias, NunoLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)ront-ndi (author)
- Pedro, Luis M. (author)
- Fernandes e Fernandes, Jose (author)
- Ares, MikkoLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)medf-mar (author)
- Ares, IsabellaLund University,Lunds universitet,Experimentell patologi, Malmö,Forskargrupper vid Lunds universitet,Experimental Pathology, Malmö,Lund University Research Groups(Swepub:lu)expp-ipo (author)
- Kardiovaskulär forskning - immunitet och aterosklerosForskargrupper vid Lunds universitet (creator_code:org_t)
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- In:BMC Cardiovascular Disorders: Springer Science and Business Media LLC9:261471-2261
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