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Complement Cascade ...
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Ceribelli, Angela
(author)
Complement Cascade in Systemic Lupus Erythematosus Analyses of the Three Activation Pathways
- Article/chapterEnglish2009
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LIBRIS-ID:oai:lup.lub.lu.se:df00e99e-b941-47b4-a854-fceaccedf112
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https://lup.lub.lu.se/record/1507017URI
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https://doi.org/10.1111/j.1749-6632.2009.04921.xDOI
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Language:English
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Summary in:English
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Subject category:kon swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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The complement (C') cascade is an important part of the innate immunity. It acts through three major pathways: classical (CP), alternative (AP) and mannose-binding-lectin (MP). C' reduction is a key feature in systemic lupus erythematosus (SLE), for its pathogenesis and for disease relapse. The aims of our study are to correlate C' variations with disease activity and verify the presence of C' deficiencies. We tested for three C' pathways 52 sera from 20 patients affected by SLE. A significant correlation between the ECLAM score and the degree of activation of the CP (Mann-Whitney; P = 0.001) was recorded, while the correlation with anti-dsDNA antibodies did not reach statistical significance (Mann-Whitney; P > 0.05). In conclusion, the ELISA assay can be considered well suited for testing SLE samples. We detected a significant link between the phases of lupus activity and the reduction of the CP.
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Andreoli, Laura
(author)
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Cavazzana, Ilaria
(author)
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Franceschini, Franco
(author)
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Radice, Antonella
(author)
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Rimoldi, Laura
(author)
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Sinico, Renato Alberto
(author)
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Carlsson, MalinLund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)njur-nca
(author)
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Wieslander, Jorgen
(author)
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Tincani, Angela
(author)
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NjurmedicinSektion II
(creator_code:org_t)
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In:Contemporary Challenges in Autoimmunity: Wiley1173, s. 427-4340077-8923
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Ceribelli, Angel ...
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Andreoli, Laura
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Cavazzana, Ilari ...
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Franceschini, Fr ...
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Radice, Antonell ...
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Rimoldi, Laura
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Sinico, Renato A ...
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Carlsson, Malin
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Wieslander, Jorg ...
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Tincani, Angela
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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Contemporary Cha ...
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Lund University