SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:df00e99e-b941-47b4-a854-fceaccedf112"
 

Search: onr:"swepub:oai:lup.lub.lu.se:df00e99e-b941-47b4-a854-fceaccedf112" > Complement Cascade ...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Ceribelli, Angela (author)

Complement Cascade in Systemic Lupus Erythematosus Analyses of the Three Activation Pathways

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-09-01
  • Wiley,2009

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:df00e99e-b941-47b4-a854-fceaccedf112
  • https://lup.lub.lu.se/record/1507017URI
  • https://doi.org/10.1111/j.1749-6632.2009.04921.xDOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:kon swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The complement (C') cascade is an important part of the innate immunity. It acts through three major pathways: classical (CP), alternative (AP) and mannose-binding-lectin (MP). C' reduction is a key feature in systemic lupus erythematosus (SLE), for its pathogenesis and for disease relapse. The aims of our study are to correlate C' variations with disease activity and verify the presence of C' deficiencies. We tested for three C' pathways 52 sera from 20 patients affected by SLE. A significant correlation between the ECLAM score and the degree of activation of the CP (Mann-Whitney; P = 0.001) was recorded, while the correlation with anti-dsDNA antibodies did not reach statistical significance (Mann-Whitney; P > 0.05). In conclusion, the ELISA assay can be considered well suited for testing SLE samples. We detected a significant link between the phases of lupus activity and the reduction of the CP.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Andreoli, Laura (author)
  • Cavazzana, Ilaria (author)
  • Franceschini, Franco (author)
  • Radice, Antonella (author)
  • Rimoldi, Laura (author)
  • Sinico, Renato Alberto (author)
  • Carlsson, MalinLund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)njur-nca (author)
  • Wieslander, Jorgen (author)
  • Tincani, Angela (author)
  • NjurmedicinSektion II (creator_code:org_t)

Related titles

  • In:Contemporary Challenges in Autoimmunity: Wiley1173, s. 427-4340077-8923

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view