Search: onr:"swepub:oai:lup.lub.lu.se:df66ec96-a467-492e-93e7-593567a0b4ab" >
An Economic Model f...
-
Schilling, ChrisUniversity of Melbourne
(author)
An Economic Model for Estimating Trial Costs with an Application to Placebo Surgery Trials
- Article/chapterEnglish2023
Publisher, publication year, extent ...
-
2022-12-28
-
Springer Science and Business Media LLC,2023
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:df66ec96-a467-492e-93e7-593567a0b4ab
-
https://lup.lub.lu.se/record/df66ec96-a467-492e-93e7-593567a0b4abURI
-
https://doi.org/10.1007/s40258-022-00775-4DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Background and Objective: Waste in clinical trials remains rife. We developed an economic model to predict the cost of trials based on input costs, duration, power, number of sites, recruitment eligibility and consenting rates. Methods: We parameterised the model for three proxy placebo-controlled surgical trials using data from a systematic review, a bespoke cost survey, and from the literature. We used the model to compare target and actual trial performance for (i) a trial that was completed on time but with more sites, (ii) a trial that completed after a time extension, and (iii) an incomplete trial. Results: Successful trials more accurately anticipated the true recruitment rate that they achieved and those that overestimated this were most likely to fail. The costs of overestimating recruitment rates were dramatic: all proxy trials had significantly higher costs than planned, with additional funding of at least AUD$600,000 (50% above budget) required for trials that completed after adding more sites or more time, and over AUD$2 million (260% above budget) for incomplete trials. Conclusions: This model shows the trade-offs between time and cost, or both, when recruitment is lower than anticipated. Greater consideration is needed to improve trial planning, reviewing, and funding of these trials to avoid costly overruns and incomplete trials.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Tew, MichelleUniversity of Melbourne
(author)
-
Bunzli, SamanthaUniversity of Melbourne
(author)
-
Shadbolt, CadeUniversity of Melbourne
(author)
-
Lohmander, L. StefanLund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Nedbrytning av ledbrosk: en biologisk process som leder till artros,Forskargrupper vid Lunds universitet,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund OsteoArthritis Division - Molecular marker research group,Lund University Research Groups(Swepub:lu)ort-slo
(author)
-
Balogh, Zsolt J.University of Newcastle
(author)
-
Paolucci, FrancescoUniversity of Bologna,University of Newcastle
(author)
-
Choong, Peter F.University of Melbourne,St. Vincent's Hospital, Melbourne
(author)
-
Dowsey, Michelle M.University of Melbourne,St. Vincent's Hospital, Melbourne
(author)
-
Clarke, PhilipUniversity of Melbourne,University of Oxford
(author)
-
University of MelbourneOrtopedi, Lund
(creator_code:org_t)
Related titles
-
In:Applied Health Economics and Health Policy: Springer Science and Business Media LLC21:2, s. 263-2731175-56521179-1896
Internet link
Find in a library
To the university's database
- By the author/editor
-
Schilling, Chris
-
Tew, Michelle
-
Bunzli, Samantha
-
Shadbolt, Cade
-
Lohmander, L. St ...
-
Balogh, Zsolt J.
-
show more...
-
Paolucci, France ...
-
Choong, Peter F.
-
Dowsey, Michelle ...
-
Clarke, Philip
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Health Care Serv ...
- Articles in the publication
-
Applied Health E ...
- By the university
-
Lund University