SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:df8b4522-b9d2-4068-9dc0-56e9c2e47d7f"
 

Search: onr:"swepub:oai:lup.lub.lu.se:df8b4522-b9d2-4068-9dc0-56e9c2e47d7f" > Attributable mortal...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004763naa a2200553 4500
001oai:lup.lub.lu.se:df8b4522-b9d2-4068-9dc0-56e9c2e47d7f
003SwePub
008160401s2013 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/40428332 URI
0247 a https://doi.org/10.1016/S1473-3099(13)70081-12 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Melsen, Wilhelmina G.4 aut
2451 0a Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies
264 1c 2013
520 a Background Estimating attributable mortality of ventilator-associated pneumonia has been hampered by confounding factors, small sample sizes, and the difficulty of doing relevant subgroup analyses. We estimated the attributable mortality using the individual original patient data of published randomised trials of ventilator-associated pneumonia prevention. Methods We identified relevant studies through systematic review. We analysed individual patient data in a one-stage meta-analytical approach (in which we defined attributable mortality as the ratio between the relative risk reductions [RRR] of mortality and ventilator-associated pneumonia) and in competing risk analyses. Predefined subgroups included surgical, trauma, and medical patients, and patients with different categories of severity of illness scores. Findings Individual patient data were available for 6284 patients from 24 trials. The overall attributable mortality was 13%, with higher mortality rates in surgical patients and patients with mid-range severity scores at admission (ie, acute physiology and chronic health evaluation score [APACHE] 20-29 and simplified acute physiology score [SAPS 2] 35-58). Attributable mortality was close to zero in trauma, medical patients, and patients with low or high severity of illness scores. Competing risk analyses could be done for 5162 patients from 19 studies, and the overall daily hazard for intensive care unit (ICU) mortality after ventilator-associated pneumonia was 1.13 (95% CI 0.98-1.31). The overall daily risk of discharge after ventilator-associated pneumonia was 0.74 (0-68-0.80), leading to an overall cumulative risk for dying in the ICU of 2.20 (1.91-2.54). Highest cumulative risks for dying from ventilator-associated pneumonia were noted for surgical patients (2.97,95% CI 2-24-3-94) and patients with mid-range severity scores at admission (ie, cumulative risks of 2.49 [1.81-3-44] for patients with APACHE scores of 20-29 and 2.72 [1.95-3.78] for those with SAPS 2 scores of 35-58). Interpretation The overall attributable mortality of ventilator-associated pneumonia is 13%, with higher rates for surgical patients and patients with a mid-range severity score at admission. Attributable mortality is mainly caused by prolonged exposure to the risk of dying due to increased length of ICU stay.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
7001 a Rovers, Maroeska M.4 aut
7001 a Groenwold, Rolf H. H.4 aut
7001 a Bergmans, Dennis C. J. J.4 aut
7001 a Camus, Christophe4 aut
7001 a Bauer, Torsten T.4 aut
7001 a Hanisch, Ernst W.4 aut
7001 a Klarin, Bengtu Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)anes-bkl
7001 a Koeman, Mirelle4 aut
7001 a Krueger, Wolfgang A.4 aut
7001 a Lacherade, Jean-Claude4 aut
7001 a Lorente, Leonardo4 aut
7001 a Memish, Ziad A.4 aut
7001 a Morrow, Lee E.4 aut
7001 a Nardi, Giuseppe4 aut
7001 a van Nieuwenhoven, Christianne A.4 aut
7001 a O'Keefe, Grant E.4 aut
7001 a Nakos, George4 aut
7001 a Scannapieco, Frank A.4 aut
7001 a Seguin, Philippe4 aut
7001 a Staudinger, Thomas4 aut
7001 a Topeli, Arzu4 aut
7001 a Ferrer, Miguel4 aut
7001 a Bonten, Marc J. M.4 aut
7102 a Anestesiologi och intensivvårdb Sektion II4 org
7730 t The Lancet. Infectious Diseasesg 13:8, s. 665-671q 13:8<665-671x 1474-4457
8564 u http://dx.doi.org/10.1016/S1473-3099(13)70081-1y FULLTEXT
8564 8u https://lup.lub.lu.se/record/4042833
8564 8u https://doi.org/10.1016/S1473-3099(13)70081-1

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view