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High serum total ch...
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Svensson, TLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,University of Tokyo,National Cancer Center Tokyo,Skåne University Hospital,Keio University
(author)
High serum total cholesterol is associated with suicide mortality in Japanese women
- Article/chapterEnglish2017
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LIBRIS-ID:oai:lup.lub.lu.se:dfe241c8-368e-4b06-b875-bfeee4d5d0f7
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https://lup.lub.lu.se/record/dfe241c8-368e-4b06-b875-bfeee4d5d0f7URI
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https://doi.org/10.1111/acps.12758DOI
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Language:English
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Summary in:English
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OBJECTIVE: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times.METHOD: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women.RESULTS: There were 185 suicides (men: 107; women: 78) during follow-up. Compared to women with normal TC, women with high TC had a significantly increased risk of suicide (HR = 1.90, 95% CI, 1.13-3.19). Incremental increases (0.26 mmol/l [10 mg/dl]) of low-density lipoprotein (HR = 1.11, 95% CI, 1.02-1.21) and non-high-density lipoprotein cholesterol (HR = 1.09, 95% CI, 1.01-1.18) were also associated with increased risk of suicide in women. There was no association between TC levels, or lipid fractions, and suicide in men.CONCLUSION: High TC levels may be associated with an increased risk of suicide in women.
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Inoue, ManamiUniversity of Tokyo
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Sawada, NorieNational Cancer Center Tokyo
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Charvat, HadrienNational Cancer Center Tokyo
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Mimura, MasaruKeio University
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Tsugane, ShoichiroNational Cancer Center Tokyo
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Kardiovaskulär forskning - hypertoniForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Acta Psychiatrica Scandinavica: Wiley136:3, s. 259-2681600-04470001-690X
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