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Association of hypo...
Association of hypogonadism with vitamin D status: the European Male Ageing Study
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Lee, David M. (author)
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Tajar, Abdelouahid (author)
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Pye, Stephen R. (author)
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Boonen, Steven (author)
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Vanderschueren, Dirk (author)
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Bouillon, Roger (author)
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O'Neill, Terence W. (author)
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Bartfai, Gyorgy (author)
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Casanueva, Felipe F. (author)
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Finn, Joseph D. (author)
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Forti, Gianni (author)
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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Han, Thang S. (author)
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Huhtaniemi, Ilpo T. (author)
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Kula, Krzysztof (author)
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Lean, Michael E. J. (author)
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Pendleton, Neil (author)
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Punab, Margus (author)
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Wu, Frederick C. W. (author)
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: European Journal of Endocrinology. - 1479-683X. ; 166:1, s. 77-85
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http://dx.doi.org/10...
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Abstract
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- Objective: Interrelationships between hormones of the hypothalamic-pituitary-testicular (HPT) axis, hypogonadism, vitamin D and seasonality remain poorly defined. We investigated whether HPT axis hormones and hypogonadism are associated with serum levels of 25-hydroxyvitamin D (25(OH)D) in men. Design and methods: Cross-sectional survey of 3369 community-dwelling men aged 40-79 years in eight European centres. Testosterone (T), oestradiol (E(2)) and dihydrotestosterone were measured by gas chromatography-mass spectrometry; LH, FSH, sex hormone binding globulin (SHBG), 25(OH)D and parathyroid hormone by immunoassay. Free T was calculated from total T, SHBG and albumin. Gonadal status was categorised as eugonadal (normal T/LH), secondary (low T, low/normal LH), primary (low T, elevated LH) and compensated (normal T, elevated LH) hypogonadism. Associations of HPT axis hormones with 25(OH)D were examined using linear regression and hypogonadism with vitamin D using multinomial logistic regression. Results: In univariate analyses, free T levels were lower (P=0.02) and E(2) and LH levels were higher (P<0.05) in men with vitamin D deficiency (25(OH)D <50 nmol/l). 25(OH)D was positively associated with total and free T and negatively with E(2) and LH in age- and centre-adjusted linear regressions. After adjusting for health and lifestyle factors, no significant associations were observed between 25(OH)D and individual hormones of the HPT axis. However, vitamin D deficiency was significantly associated with compensated (relative risk ratio (RRR)=1.52, P=0.03) and secondary hypogonadism (RRR=1.16, P=0.05). Seasonal variation was only observed for 25(OH)D (P<0.001). Conclusions: Secondary and compensated hypogonadism were associated with vitamin D deficiency and the clinical significance of this relationship warrants further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Lee, David M.
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Tajar, Abdelouah ...
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Pye, Stephen R.
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Boonen, Steven
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Vanderschueren, ...
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Bouillon, Roger
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show more...
-
O'Neill, Terence ...
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Bartfai, Gyorgy
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Casanueva, Felip ...
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Finn, Joseph D.
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Forti, Gianni
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Giwercman, Aleks ...
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Han, Thang S.
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Huhtaniemi, Ilpo ...
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Kula, Krzysztof
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Lean, Michael E. ...
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Pendleton, Neil
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Punab, Margus
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Wu, Frederick C. ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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European Journal ...
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Lund University