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miR-126 Regulates D...
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.
- Article/chapterEnglish2016
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LIBRIS-ID:oai:lup.lub.lu.se:e1407822-759c-46a3-af5a-ceed348f9e92
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https://lup.lub.lu.se/record/8829996URI
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https://doi.org/10.1016/j.ccell.2015.12.011DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we generated a prognostic LSC-associated miRNA signature derived from functionally validated subpopulations of AML samples. For one signature miRNA, miR-126, high bioactivity aggregated all in vivo patient sample LSC activity into a single sorted population, tightly coupling miR-126 expression to LSC function. Through functional studies, miR-126 was found to restrain cell cycle progression, prevent differentiation, and increase self-renewal of primary LSC in vivo. Compared with prior results showing miR-126 regulation of normal hematopoietic stem cell (HSC) cycling, these functional stem effects are opposite between LSC and HSC. Combined transcriptome and proteome analysis demonstrates that miR-126 targets the PI3K/AKT/MTOR signaling pathway, preserving LSC quiescence and promoting chemotherapy resistance.
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Gentner, Bernhard
(author)
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Ng, Stanley W K
(author)
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Schoof, Erwin M
(author)
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van Galen, Peter
(author)
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Kennedy, James A
(author)
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Nucera, Silvia
(author)
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Ciceri, Fabio
(author)
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Kaufmann, Kerstin B
(author)
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Takayama, Naoya
(author)
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Dobson, Stephanie M
(author)
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Trotman-Grant, Aaron
(author)
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Krivdova, Gabriela
(author)
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Elzinga, Janneke
(author)
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Mitchell, Amanda
(author)
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Nilsson, BjörnLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)klin-bni
(author)
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Hermans, Karin G
(author)
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Eppert, Kolja
(author)
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Marke, Rene
(author)
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Isserlin, Ruth
(author)
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Voisin, Veronique
(author)
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Bader, Gary D
(author)
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Zandstra, Peter W
(author)
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Golub, Todd R
(author)
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Ebert, Benjamin L
(author)
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Lu, Jun
(author)
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Minden, Mark
(author)
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Wang, Jean C Y
(author)
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Naldini, Luigi
(author)
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Dick, John E
(author)
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Avdelningen för hematologi och transfusionsmedicinInstitutionen för laboratoriemedicin
(creator_code:org_t)
Related titles
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In:Cancer Cell: Elsevier BV29:2, s. 214-2281878-36861535-6108
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Lechman, Eric R
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Gentner, Bernhar ...
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Ng, Stanley W K
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Schoof, Erwin M
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van Galen, Peter
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Kennedy, James A
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show more...
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Nucera, Silvia
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Ciceri, Fabio
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Kaufmann, Kersti ...
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Takayama, Naoya
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Dobson, Stephani ...
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Trotman-Grant, A ...
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Krivdova, Gabrie ...
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Elzinga, Janneke
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Mitchell, Amanda
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Nilsson, Björn
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Hermans, Karin G
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Eppert, Kolja
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Marke, Rene
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Isserlin, Ruth
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Voisin, Veroniqu ...
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Bader, Gary D
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Zandstra, Peter ...
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Golub, Todd R
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Ebert, Benjamin ...
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Lu, Jun
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Minden, Mark
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Wang, Jean C Y
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Naldini, Luigi
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Dick, John E
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Cancer Cell
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Lund University