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Prevalence studies ...
Prevalence studies of GB virus-C infection using reverse transcriptase-polymerase chain reaction
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Dawson, George J. (author)
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Schlauder, George G. (author)
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Pilot-Matias, Tami J. (author)
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Thiele, Dwain (author)
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Leary, Thomas P. (author)
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Murphy, Paul (author)
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Rosenblatt, Jon E (author)
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Simons, John N. (author)
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Martinson, Francis E.A. (author)
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Gutierrez, Robin A. (author)
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Lentino, Joseph R. (author)
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Pachucki, Constance (author)
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Muerhoff, A. Scott (author)
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- Widell, Anders (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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Tegtmeier, Gary (author)
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Desai, Suresh (author)
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Mushahwar, Isa K. (author)
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(creator_code:org_t)
- 1996
- 1996
- English.
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In: Journal of Medical Virology. - 1096-9071. ; 50:1, s. 97-103
- Related links:
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https://lup.lub.lu.s...
Abstract
Subject headings
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- Among the three recently described GB viruses (GBV-A, GBV-B, and GBV-C), only GBV-C has been linked to cryptogenic hepatitis in man. Because of the limited utility of currently available research tests to determine antibody response to GBV-C proteins, the prevalence of GBV-C RNA in human sera was studied using reverse transcription-polymerase chain reaction (RT-PCR). The prevalence of GBV-C is higher among volunteer blood donors with elevated serum alanine aminotransferase (ALT) levels (3.9%) than among volunteer blood donors with normal ALT levels (0.8%). Higher rates were also noted among commercial blood donors (12.9%) and intravenous drug users (16.0%). GBV-C was frequently detected in residents of West Africa, where the prevalence was > 10% in most age groups. Approximately 20% of patients diagnosed with either acute or chronic hepatitis C virus (HCV) were found to be positive for GBV-C RNA. In addition, GBV-C RNA sequences were detected in individuals diagnosed with non-A-E hepatitis, with clinical courses ranging from mild disease to fulminant hepatitis. Fourteen of sixteen subjects with or without clinically apparent hepatitis were positive for GBV-C RNA more than 1 year after the initial positive result.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- HCV
- GBV-C
- hepatitis
Publication and Content Type
- art (subject category)
- ref (subject category)
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Dawson, George J ...
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Schlauder, Georg ...
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Pilot-Matias, Ta ...
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Thiele, Dwain
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Leary, Thomas P.
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Murphy, Paul
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show more...
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Rosenblatt, Jon ...
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Simons, John N.
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Martinson, Franc ...
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Gutierrez, Robin ...
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Lentino, Joseph ...
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Pachucki, Consta ...
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Muerhoff, A. Sco ...
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Widell, Anders
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Tegtmeier, Gary
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Desai, Suresh
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Mushahwar, Isa K ...
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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Journal of Medic ...
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Lund University