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Endogenous hormones...
Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European Male Ageing Study
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Lee, David M. (author)
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Ulubaev, Aslan (author)
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Tajar, Abdelouahid (author)
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Pye, Stephen R. (author)
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Pendleton, Neil (author)
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Purandare, Nitin (author)
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O'Neill, Terence W. (author)
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O'Connor, Daryl B. (author)
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Labrie, Fernand (author)
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Platt, Hazel (author)
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Payne, Debbie (author)
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Bartfai, Gyorgy (author)
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Boonen, Steven (author)
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Casanueva, Felipe F. (author)
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Finn, Joseph D. (author)
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Forti, Gianni (author)
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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Han, Thang S. (author)
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Huhtaniemi, Ilpo T. (author)
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Kula, Krzysztof (author)
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Lean, Michael E. J. (author)
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Punab, Margus (author)
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Silman, Alan J. (author)
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Vanderschueren, Dirk (author)
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Wu, Frederick C. W. (author)
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: European Journal of Endocrinology. - 1479-683X. ; 162:6, s. 1155-1164
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http://dx.doi.org/10...
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Abstract
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- Objective: Data remain divergent regarding the activational effects of endogenous hormones on adult cognitive function. We examined the association between cognition, hormones and androgen receptor (AR) CAG repeat length in a large cohort of men. Design: Community-based, cross-sectional study of 3369 men aged 40-79 years. Methods: Cognition tests were the Rey-Osterrieth Complex Figure, Camden Topographical Recognition Memory and Digit-Symbol Substitution. A fluid cognition (FC) z-score was computed from the individual tests. Testosterone, oestradiol (OE2) and 5 alpha-dihydrotestosterone were measured by gas chromatography-mass spectrometry; DHEAS, LH, FSH and sex hormone-binding globulin (SHBG) by electrochemiluminescence. Free testosterone and OE2 were calculated from total hormone, SHBG and albumin. CAG repeat lengths were assayed by PCR genotyping. Results: Total testosterone and free testosterone were associated with higher FC z-scores, LH and FSH with lower FC z-scores in age-adjusted linear regressions. After adjusting for health, lifestyle and centre, a modest association was only observed between DHEAS and a lower FC z-score (beta=-0.011, P=0.02), although this was driven by subjects with DHEAS levels > 10 mu mol/l. Locally weighted plots revealed no threshold effects between hormones and FC. There was no association between CAG repeat length and FC z-score after adjustment for age and centre (beta=-0.007, P=0.06), nor any interaction effect between CAG repeat length and hormones. Conclusion: Our results suggest that endogenous hormones are not associated with a vision-based measure of FC among healthy, community-dwelling men. Further studies are warranted to determine whether 'high' DHEAS levels are associated with poorer performance on a broader range of neuropsychological tests.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Lee, David M.
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Ulubaev, Aslan
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Tajar, Abdelouah ...
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Pye, Stephen R.
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Pendleton, Neil
-
Purandare, Nitin
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show more...
-
O'Neill, Terence ...
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O'Connor, Daryl ...
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Labrie, Fernand
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Platt, Hazel
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Payne, Debbie
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Bartfai, Gyorgy
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Boonen, Steven
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Casanueva, Felip ...
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Finn, Joseph D.
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Forti, Gianni
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Giwercman, Aleks ...
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Han, Thang S.
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Huhtaniemi, Ilpo ...
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Kula, Krzysztof
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Lean, Michael E. ...
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Punab, Margus
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Silman, Alan J.
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Vanderschueren, ...
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Wu, Frederick C. ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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European Journal ...
- By the university
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Lund University