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  • Visser, DeniseVrije Universiteit Amsterdam (author)

Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer’s disease

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-08
  • Springer Science and Business Media LLC,2022

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  • LIBRIS-ID:oai:lup.lub.lu.se:e1f41840-1d6d-462e-b7ec-3c22859c48fc
  • https://lup.lub.lu.se/record/e1f41840-1d6d-462e-b7ec-3c22859c48fcURI
  • https://doi.org/10.1007/s00259-021-05669-6DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

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  • Purpose: Early-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD) differ in neuropathological burden and type of cognitive deficits. Assessing tau pathology and relative cerebral blood flow (rCBF) measured with [18F]flortaucipir PET in relation to cognition may help explain these differences between EOAD and LOAD. Methods: Seventy-nine amyloid-positive individuals with a clinical diagnosis of AD (EOAD: n = 35, age-at-PET = 59 ± 5, MMSE = 23 ± 4; LOAD: n = 44, age-at-PET = 71 ± 5, MMSE = 23 ± 4) underwent a 130-min dynamic [18F]flortaucipir PET scan and extensive neuropsychological assessment. We extracted binding potentials (BPND) and R1 (proxy of rCBF) from parametric images using receptor parametric mapping, in medial and lateral temporal, parietal, occipital, and frontal regions-of-interest and used nine neuropsychological tests covering memory, attention, language, and executive functioning. We first examined differences between EOAD and LOAD in BPND or R1 using ANOVA (region-of-interest analysis) and voxel-wise contrasts. Next, we performed linear regression models to test for potential interaction effects between age-at-onset and BPND/R1 on cognition. Results: Both region-of-interest and voxel-wise contrasts showed higher [18F]flortaucipir BPND values across all neocortical regions in EOAD. By contrast, LOAD patients had lower R1 values (indicative of more reduced rCBF) in medial temporal regions. For both tau and flow in lateral temporal, and occipitoparietal regions, associations with cognitive impairment were stronger in EOAD than in LOAD (EOAD BPND − 0.76 ≤ stβ ≤ − 0.48 vs LOAD − 0.18 ≤ stβ ≤ − 0.02; EOAD R1 0.37 ≤ stβ ≤ 0.84 vs LOAD − 0.25 ≤ stβ ≤ 0.16). Conclusions: Compared to LOAD, the degree of lateral temporal and occipitoparietal tau pathology and relative cerebral blood-flow is more strongly associated with cognition in EOAD.

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  • Verfaillie, Sander C.J.Vrije Universiteit Amsterdam (author)
  • Wolters, Emma E.Vrije Universiteit Amsterdam (author)
  • Coomans, Emma M.Vrije Universiteit Amsterdam (author)
  • Timmers, TessaVrije Universiteit Amsterdam (author)
  • Tuncel, HayelVrije Universiteit Amsterdam (author)
  • Boellaard, RonaldVrije Universiteit Amsterdam (author)
  • Golla, Sandeep S.V.Vrije Universiteit Amsterdam (author)
  • Windhorst, Albert D.Vrije Universiteit Amsterdam (author)
  • Scheltens, PhilipVrije Universiteit Amsterdam (author)
  • van der Flier, Wiesje M.Vrije Universiteit Amsterdam (author)
  • van Berckel, Bart N.M.Vrije Universiteit Amsterdam (author)
  • Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam(Swepub:lu)ri1513os (author)
  • Vrije Universiteit AmsterdamKlinisk minnesforskning (creator_code:org_t)

Related titles

  • In:European Journal of Nuclear Medicine and Molecular Imaging: Springer Science and Business Media LLC49:6, s. 1951-19631619-70701619-7089

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