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  • Alizadehheidari, Mohammadreza,1987Chalmers tekniska högskola,Chalmers University of Technology (author)

Nanoconfined Circular and Linear DNA: Equilibrium Conformations and Unfolding Kinetics

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-01-29
  • American Chemical Society (ACS),2015

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:e20a5103-01ae-48a3-bf5d-93f79b9ea1b7
  • https://lup.lub.lu.se/record/5160190URI
  • https://doi.org/10.1021/ma5022067DOI
  • https://research.chalmers.se/publication/214195URI
  • https://gup.ub.gu.se/publication/214195URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-248190URI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Studies of circular DNA confined to nanofluidic channels are relevant both from a fundamental polymer-physics perspective and due to the importance of circular DNA molecules in vivo. We here observe the unfolding of confined DNA from the circular to linear configuration as a light-induced double-strand break occurs, characterize the dynamics, and compare the equilibrium conformational statistics of linear and circular configurations. This is important because it allows us to determine to what extent existing statistical theories describe the extension of confined circular DNA. We find that the ratio of the extensions of confined linear and circular DNA configurations increases as the buffer concentration decreases. The experimental results fall between theoretical predictions for the extended de Gennes regime at weaker confinement and the Odijk regime at stronger confinement. We show that it is possible to directly distinguish between circular and linear DNA molecules by measuring the emission intensity from the DNA. Finally, we determine the rate of unfolding and show that this rate is larger for more confined DNA, possibly reflecting the corresponding larger difference in entropy between the circular and linear configurations.

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  • Werner, ErikGothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Department of Physics (GU)(Swepub:gu)xwerne (author)
  • Noble, CharlestonLund University,Lunds universitet,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Beräkningsbiologi och biologisk fysik - Genomgår omorganisation,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Computational Biology and Biological Physics - Undergoing reorganization,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science(Swepub:lu)thep-can (author)
  • Reiter-Schad, MichaelaLund University,Lunds universitet,Beräkningsbiologi och biologisk fysik - Genomgår omorganisation,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Computational Biology and Biological Physics - Undergoing reorganization,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science(Swepub:lu)thep-mls (author)
  • Nyberg, Lena,1979Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)lnyberg (author)
  • Fritzsche, Joachim,1977Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)joafri (author)
  • Mehlig, Bernhard,1964Gothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Department of Physics (GU)(Swepub:gu)xmehbe (author)
  • Tegenfeldt, JonasLund University,Lunds universitet,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH(Swepub:gu)xjonte (author)
  • Ambjörnsson, TobiasLund University,Lunds universitet,Beräkningsbiologi och biologisk fysik - Genomgår omorganisation,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Computational Biology and Biological Physics - Undergoing reorganization,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science(Swepub:cth)tfyta (author)
  • Persson, FredrikUppsala universitet,Institutionen för cell- och molekylärbiologi (author)
  • Westerlund, Fredrik,1978Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)fredrikw (author)
  • Chalmers tekniska högskolaInstitutionen för fysik (GU) (creator_code:org_t)

Related titles

  • In:Macromolecules: American Chemical Society (ACS)48:3, s. 871-8780024-92971520-5835

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