Search: onr:"swepub:oai:lup.lub.lu.se:e20a5103-01ae-48a3-bf5d-93f79b9ea1b7" >
Nanoconfined Circul...
-
Alizadehheidari, Mohammadreza,1987Chalmers tekniska högskola,Chalmers University of Technology
(author)
Nanoconfined Circular and Linear DNA: Equilibrium Conformations and Unfolding Kinetics
- Article/chapterEnglish2015
Publisher, publication year, extent ...
-
2015-01-29
-
American Chemical Society (ACS),2015
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:e20a5103-01ae-48a3-bf5d-93f79b9ea1b7
-
https://lup.lub.lu.se/record/5160190URI
-
https://doi.org/10.1021/ma5022067DOI
-
https://research.chalmers.se/publication/214195URI
-
https://gup.ub.gu.se/publication/214195URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-248190URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Studies of circular DNA confined to nanofluidic channels are relevant both from a fundamental polymer-physics perspective and due to the importance of circular DNA molecules in vivo. We here observe the unfolding of confined DNA from the circular to linear configuration as a light-induced double-strand break occurs, characterize the dynamics, and compare the equilibrium conformational statistics of linear and circular configurations. This is important because it allows us to determine to what extent existing statistical theories describe the extension of confined circular DNA. We find that the ratio of the extensions of confined linear and circular DNA configurations increases as the buffer concentration decreases. The experimental results fall between theoretical predictions for the extended de Gennes regime at weaker confinement and the Odijk regime at stronger confinement. We show that it is possible to directly distinguish between circular and linear DNA molecules by measuring the emission intensity from the DNA. Finally, we determine the rate of unfolding and show that this rate is larger for more confined DNA, possibly reflecting the corresponding larger difference in entropy between the circular and linear configurations.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Werner, ErikGothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Department of Physics (GU)(Swepub:gu)xwerne
(author)
-
Noble, CharlestonLund University,Lunds universitet,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Beräkningsbiologi och biologisk fysik - Genomgår omorganisation,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Computational Biology and Biological Physics - Undergoing reorganization,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science(Swepub:lu)thep-can
(author)
-
Reiter-Schad, MichaelaLund University,Lunds universitet,Beräkningsbiologi och biologisk fysik - Genomgår omorganisation,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Computational Biology and Biological Physics - Undergoing reorganization,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science(Swepub:lu)thep-mls
(author)
-
Nyberg, Lena,1979Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)lnyberg
(author)
-
Fritzsche, Joachim,1977Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)joafri
(author)
-
Mehlig, Bernhard,1964Gothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Department of Physics (GU)(Swepub:gu)xmehbe
(author)
-
Tegenfeldt, JonasLund University,Lunds universitet,Fasta tillståndets fysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Solid State Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH(Swepub:gu)xjonte
(author)
-
Ambjörnsson, TobiasLund University,Lunds universitet,Beräkningsbiologi och biologisk fysik - Genomgår omorganisation,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Computational Biology and Biological Physics - Undergoing reorganization,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science(Swepub:cth)tfyta
(author)
-
Persson, FredrikUppsala universitet,Institutionen för cell- och molekylärbiologi
(author)
-
Westerlund, Fredrik,1978Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)fredrikw
(author)
-
Chalmers tekniska högskolaInstitutionen för fysik (GU)
(creator_code:org_t)
Related titles
-
In:Macromolecules: American Chemical Society (ACS)48:3, s. 871-8780024-92971520-5835
Internet link
Find in a library
To the university's database
- By the author/editor
-
Alizadehheidari, ...
-
Werner, Erik
-
Noble, Charlesto ...
-
Reiter-Schad, Mi ...
-
Nyberg, Lena, 19 ...
-
Fritzsche, Joach ...
-
show more...
-
Mehlig, Bernhard ...
-
Tegenfeldt, Jona ...
-
Ambjörnsson, Tob ...
-
Persson, Fredrik
-
Westerlund, Fred ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Physical Science ...
-
and Condensed Matter ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Biophysics
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Physical Science ...
-
and Other Physics To ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Physical Science ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Cell Biology
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Biochemistry and ...
- Articles in the publication
-
Macromolecules
- By the university
-
Lund University
-
Chalmers University of Technology
-
University of Gothenburg
-
Uppsala University