Genome-wide meta-analyses identify multiple loci associated with smoking behavior

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Furberg, Helena (author)

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

Article/chapterEnglish2010

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2010-04-25
Springer Science and Business Media LLC,2010

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LIBRIS-ID:oai:lup.lub.lu.se:e24186cf-b864-4612-9009-34dafc946a18
https://lup.lub.lu.se/record/1619189URI
https://doi.org/10.1038/ng.571DOI

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Language:English
Summary in:English

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Consistent but indirect evidence has implicated genetic factors in smoking behavior1,2. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic Epidemiology (ENGAGE) and Oxford-GlaxoSmithKline (Ox-GSK) consortia to follow up the 15 most significant regions (n > 140,000). We identified three loci associated with number of cigarettes smoked per day. The strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3 (rs1051730[A], b = 1.03, standard error (s.e.) = 0.053, beta = 2.8 x 10(-73)). Two 10q25 SNPs (rs1329650[G], b = 0.367, s. e. = 0.059, beta = 5.7 x 10(-10); and rs1028936[A], b = 0.446, s. e. = 0.074, beta = 1.3 x 10(-9)) and one 9q13 SNP in EGLN2 (rs3733829[G], b = 0.333, s. e. = 0.058, P = 1.0 x 10(-8)) also exceeded genome-wide significance for cigarettes per day. For smoking initiation, eight SNPs exceeded genome-wide significance, with the strongest association at a nonsynonymous SNP in BDNF on chromosome 11 (rs6265[C], odds ratio (OR) = 1.06, 95% confidence interval (Cl) 1.04-1.08, P = 1.8 x 10(-8)). One SNP located near DBH on chromosome 9 (rs3025343[G], OR = 1.12, 95% Cl 1.08-1.18, P = 3.6 x 10(-8)) was significantly associated with smoking cessation.

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Kim, YunJung (author)
Dackor, Jennifer (author)
Boerwinkle, Eric (author)
Franceschini, Nora (author)
Ardissino, Diego (author)
Bernardinelli, Luisa (author)
Mannucci, Pier M. (author)
Mauri, Francesco (author)
Merlini, Piera A. (author)
Absher, Devin (author)
Assimes, Themistocles L. (author)
Fortmann, Stephen P. (author)
Iribarren, Carlos (author)
Knowles, Joshua W. (author)
Quertermous, Thomas (author)
Ferrucci, Luigi (author)
Tanaka, Toshiko (author)
Bis, Joshua C. (author)
Furberg, Curt D. (author)
Haritunians, Talin (author)
McKnight, Barbara (author)
Psaty, Bruce M. (author)
Taylor, Kent D. (author)
Thacker, Evan L. (author)
Almgren, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-pal (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Ladenvall, ClaesLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-cll (author)
Boehnke, Michael (author)
Jackson, Anne U. (author)
Mohlke, Karen L. (author)
Stringham, Heather M. (author)
Tuomilehto, Jaakko (author)
Benjamin, Emelia J. (author)
Hwang, Shih-Jen (author)
Levy, Daniel (author)
Preis, Sarah Rosner (author)
Vasan, Ramachandran S. (author)
Duan, Jubao (author)
Gejman, Pablo V. (author)
Levinson, Douglas F. (author)
Sanders, Alan R. (author)
Shi, Jianxin (author)
Lips, Esther H. (author)
Mckay, James D. (author)
Agudo, Antonio (author)
Barzan, Luigi (author)
Bencko, Vladimir (author)
Benhamou, Simone (author)
Castellsague, Xavier (author)
Canova, Cristina (author)
Conway, David I. (author)
Fabianova, Eleonora (author)
Foretova, Lenka (author)
Janout, Vladimir (author)
Healy, Claire M. (author)
Holcatova, Ivana (author)
Kjaerheim, Kristina (author)
Lagiou, Pagona (author)
Lissowska, Jolanta (author)
Lowry, Ray (author)
Macfarlane, Tatiana V. (author)
Mates, Dana (author)
Richiardi, Lorenzo (author)
Rudnai, Peter (author)
Szeszenia-Dabrowska, Neonilia (author)
Zaridze, David (author)
Znaor, Ariana (author)
Lathrop, Mark (author)
Brennan, Paul (author)
Bandinelli, Stefania (author)
Frayling, Timothy M. (author)
Guralnik, Jack M. (author)
Milaneschi, Yuri (author)
Perry, John R. B. (author)
Altshuler, David (author)
Elosua, Roberto (author)
Kathiresan, Sek (author)
Lucas, Gavin (author)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
O'Donnell, Christopher J. (author)
Salomaa, Veikko (author)
Schwartz, Stephen M. (author)
Voight, Benjamin F. (author)
Penninx, Brenda W. (author)
Smit, Johannes H. (author)
Vogelzangs, Nicole (author)
Boomsma, Dorret I. (author)
de Geus, Eco J. C. (author)
Vink, Jacqueline M. (author)
Willemsen, Gonneke (author)
Chanock, Stephen J. (author)
Gu, Fangyi (author)
Hankinson, Susan E. (author)
Hunter, David J. (author)
Hofman, Albert (author)
Tiemeier, Henning (author)
Uitterlinden, Andre G. (author)
van Duijn, Cornelia M. (author)
Walter, Stefan (author)
Chasman, Daniel I. (author)
Everett, Brendan M. (author)
Pare, Guillaume (author)
Ridker, Paul M. (author)
Li, Ming D. (author)
Maes, Hermine H. (author)
Audrain-McGovern, Janet (author)
Posthuma, Danielle (author)
Thornton, Laura M. (author)
Lerman, Caryn (author)
Kaprio, Jaakko (author)
Rose, Jed E. (author)
Ioannidis, John P. A. (author)
Kraft, Peter (author)
Lin, Dan-Yu (author)
Sullivan, Patrick F. (author)
Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC42:5, s. 134-4411546-17181061-4036

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By the author/editor: Furberg, Helena; Kim, YunJung; Dackor, Jennifer; Boerwinkle, Eric; Franceschini, No ...; Ardissino, Diego; show more...; Bernardinelli, L ...; Mannucci, Pier M ...; Mauri, Francesco; Merlini, Piera A ...; Absher, Devin; Assimes, Themist ...; Fortmann, Stephe ...; Iribarren, Carlo ...; Knowles, Joshua ...; Quertermous, Tho ...; Ferrucci, Luigi; Tanaka, Toshiko; Bis, Joshua C.; Furberg, Curt D.; Haritunians, Tal ...; McKnight, Barbar ...; Psaty, Bruce M.; Taylor, Kent D.; Thacker, Evan L.; Almgren, Peter; Groop, Leif; Ladenvall, Claes; Boehnke, Michael; Jackson, Anne U.; Mohlke, Karen L.; Stringham, Heath ...; Tuomilehto, Jaak ...; Benjamin, Emelia ...; Hwang, Shih-Jen; Levy, Daniel; Preis, Sarah Ros ...; Vasan, Ramachand ...; Duan, Jubao; Gejman, Pablo V.; Levinson, Dougla ...; Sanders, Alan R.; Shi, Jianxin; Lips, Esther H.; Mckay, James D.; Agudo, Antonio; Barzan, Luigi; Bencko, Vladimir; Benhamou, Simone; Castellsague, Xa ...; Canova, Cristina; Conway, David I.; Fabianova, Eleon ...; Foretova, Lenka; Janout, Vladimir; Healy, Claire M.; Holcatova, Ivana; Kjaerheim, Krist ...; Lagiou, Pagona; Lissowska, Jolan ...; Lowry, Ray; Macfarlane, Tati ...; Mates, Dana; Richiardi, Loren ...; Rudnai, Peter; Szeszenia-Dabrow ...; Zaridze, David; Znaor, Ariana; Lathrop, Mark; Brennan, Paul; Bandinelli, Stef ...; Frayling, Timoth ...; Guralnik, Jack M ...; Milaneschi, Yuri; Perry, John R. B ...; Altshuler, David; Elosua, Roberto; Kathiresan, Sek; Lucas, Gavin; Melander, Olle; O'Donnell, Chris ...; Salomaa, Veikko; Schwartz, Stephe ...; Voight, Benjamin ...; Penninx, Brenda ...; Smit, Johannes H ...; Vogelzangs, Nico ...; Boomsma, Dorret ...; de Geus, Eco J. ...; Vink, Jacqueline ...; Willemsen, Gonne ...; Chanock, Stephen ...; Gu, Fangyi; Hankinson, Susan ...; Hunter, David J.; Hofman, Albert; Tiemeier, Hennin ...; Uitterlinden, An ...; van Duijn, Corne ...; Walter, Stefan; Chasman, Daniel ...; Everett, Brendan ...; Pare, Guillaume; Ridker, Paul M.; Li, Ming D.; Maes, Hermine H.; Audrain-McGovern ...; Posthuma, Daniel ...; Thornton, Laura ...; Lerman, Caryn; Kaprio, Jaakko; Rose, Jed E.; Ioannidis, John ...; Kraft, Peter; Lin, Dan-Yu; Sullivan, Patric ...; show less...

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