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Switching clotting ...
Switching clotting factor concentrates: considerations in estimating the risk of immunogenicity
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Matino, D. (author)
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Lillicrap, D. (author)
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- Astermark, Jan (author)
- Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups
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Dolan, G. (author)
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Kessler, C. (author)
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Lambert, T. (author)
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Makris, M. (author)
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O'Donnell, J. (author)
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Pipe, S. (author)
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Santagostino, E. (author)
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Saint-Remy, J. -M. (author)
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Schramm, W. (author)
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Iorio, A. (author)
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(creator_code:org_t)
- 2013-10-29
- 2014
- English.
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In: Haemophilia. - : Wiley. - 1351-8216. ; 20:2, s. 200-206
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Abstract
Subject headings
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- The development of neutralizing antibodies to factor VIII (FVIII) is the most serious complication of therapy for haemophilia A. There is now excellent documentation that a large number of both genetic and environmental factors contribute to the risk of FVIII inhibitor incidence. One of the environmental factors that has been proposed as an influence on this complication is the occurrence of FVIII product switching. There are only a small number of clinical studies that have addressed this question, and thus, the amount of objective information available to assess this association is limited. In this review, in addition to summarizing past evidence pertinent to this subject, we present the results of a complementary strategy, a Delphi analysis, to add to the considerations of product switching and FVIII immunogenicity. With the imminent arrival in the clinic of several new FVIII products, the haemophilia community must be prepared to collect prospectively controlled data to better address this important management issue.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Matino, D.
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Lillicrap, D.
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Astermark, Jan
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Dolan, G.
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Kessler, C.
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Lambert, T.
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show more...
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Makris, M.
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O'Donnell, J.
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Pipe, S.
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Santagostino, E.
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Saint-Remy, J. - ...
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Schramm, W.
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Iorio, A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Haemophilia
- By the university
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Lund University