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Gonadal sex steroid...
Gonadal sex steroid status and bone health in middle-aged and elderly European men
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Vanderschueren, D. (author)
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Pye, S. R. (author)
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Venken, K. (author)
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Borghs, H. (author)
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Gaytant, J. (author)
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Huhtaniemi, I. T. (author)
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Adams, J. E. (author)
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Ward, K. A. (author)
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Bartfai, G. (author)
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Casanueva, F. F. (author)
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Finn, J. D. (author)
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Forti, G. (author)
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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Han, T. S. (author)
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Kula, K. (author)
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Labrie, F. (author)
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Lean, M. E. J. (author)
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Pendleton, N. (author)
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Punab, M. (author)
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Silman, A. J. (author)
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Wu, F. C. W. (author)
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O'Neill, T. W. (author)
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Boonen, S. (author)
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(creator_code:org_t)
- 2009-12-15
- 2010
- English.
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In: Osteoporosis International. - : Springer Science and Business Media LLC. - 1433-2965 .- 0937-941X. ; 21:8, s. 1331-1339
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The influence of sex steroids on calcaneal quantitative ultrasound (QUS) parameters was assessed in a population sample of middle-aged and elderly European men. Higher free and total E-2 though not testosterone, were independently associated with higher QUS parameters. The aim of this study was to investigate the association between QUS parameters and sex steroids in middle-aged and elderly European men. Three thousand one hundred forty-one men aged between 40 and 79 years were recruited from eight European centres for participation in a study of male ageing: the European Male Ageing Study. Subjects were invited by letter to attend for an interviewer-administered questionnaire, blood sample and QUS of the calcaneus (Hologic-SAHARA). Blood was assessed for sex steroids including oestradiol (E-2), testosterone (T), free and bio-available E-2 and T and sex hormone binding globulin (SHBG). Serum total T was not associated with any of the QUS parameters. Free T and both free and total E-2 were positively related to all QUS readings, while SHBG concentrations were negatively associated. These relationships were observed in both older and younger (< 60 years) men. In a multivariate model, after adjustment for age, centre, height, weight, physical activity levels and smoking, free E-2 and SHBG, though not free T, remained independently associated with the QUS parameters. After further adjustment for IGF-1, however, the association with SHBG became non-significant. Higher free and total E-2 are associated with bone health not only among the elderly but also middle-aged European men.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Testosterone
- SHBG
- Sex steroids
- Epidemiology
- Oestradiol
- Ultrasound
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Vanderschueren, ...
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Pye, S. R.
-
Venken, K.
-
Borghs, H.
-
Gaytant, J.
-
Huhtaniemi, I. T ...
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show more...
-
Adams, J. E.
-
Ward, K. A.
-
Bartfai, G.
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Casanueva, F. F.
-
Finn, J. D.
-
Forti, G.
-
Giwercman, Aleks ...
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Han, T. S.
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Kula, K.
-
Labrie, F.
-
Lean, M. E. J.
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Pendleton, N.
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Punab, M.
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Silman, A. J.
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Wu, F. C. W.
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O'Neill, T. W.
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Boonen, S.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Osteoporosis Int ...
- By the university
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Lund University