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The European Leukem...
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Cornelissen, Jan J.
(author)
The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-09-04
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Springer Science and Business Media LLC,2012
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electronicrdacarrier
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LIBRIS-ID:oai:lup.lub.lu.se:e3559261-6d75-4b45-9a5d-4fdfa8c1eb19
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https://lup.lub.lu.se/record/3184309URI
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https://doi.org/10.1038/nrclinonc.2012.150DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:for swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Allogeneic haematopoietic stem-cell transplantation (HSCT) is frequently applied as part of the treatment in patients with acute myeloid leukaemia (AML) in their first or subsequent remission. Allogeneic HSCT reduces relapse, but nonrelapse mortality and morbidity might counterbalance this beneficial effect. Here, we review recent studies reporting new disease-specific prognostic markers, in addition to allogeneic-HSCT-related risk factors, which can be assessed at specific time points during treatment. We propose risk assessment as a dynamic process during treatment, incorporating both disease-related and transplant-related factors for the decision to proceed either to allogeneic HSCT or to apply a nontransplant strategy. We suggest that allogeneic HSCT might be favoured if the projected disease-free survival is expected to improve by at least 10% based on an individual's risk assessment. The approach requires initial disease risk assessment, identifying a sibling or unrelated donor soon after diagnosis and the incorporation of time-dependent risk factors, all within the context of an integrated therapeutic management approach.
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Gratwohl, Alois
(author)
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Schlenk, Richard F.
(author)
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Sierra, Jorge
(author)
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Bornhaeuser, Martin
(author)
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Juliusson, GunnarLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-gju
(author)
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Racil, Zdenek
(author)
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Rowe, Jacob M.
(author)
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Russell, Nigel
(author)
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Mohty, Mohamad
(author)
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Lowenberg, Bob
(author)
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Socie, Gerard
(author)
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Niederwieser, Dietger
(author)
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Ossenkoppele, Gert J.
(author)
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Stamcellscentrum (SCC)Avdelningen för stamcellsforskning
(creator_code:org_t)
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In:Nature Reviews Clinical Oncology: Springer Science and Business Media LLC9:10, s. 579-5901759-47821759-4774
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Cornelissen, Jan ...
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Gratwohl, Alois
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Sierra, Jorge
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Racil, Zdenek
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Rowe, Jacob M.
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Russell, Nigel
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Mohty, Mohamad
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Lowenberg, Bob
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Socie, Gerard
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Niederwieser, Di ...
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Ossenkoppele, Ge ...
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