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A locus on 19p13 mo...
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Antoniou, Antonis C.
(author)
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-09-19
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Springer Science and Business Media LLC,2010
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:e3b8ea03-2f13-4a39-ab70-4acd450f7cad
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https://lup.lub.lu.se/record/1694599URI
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https://doi.org/10.1038/ng.669DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121345334URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134677URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 BRCA1 carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 BRCA1 carriers (2,974 individuals with breast cancer and 3,012 unaffected individuals). Five SNPs on 19p13 were associated with breast cancer risk (P-trend = 2.3 x 10(-9) to Ptrend = 3.9 x 10(-7)), two of which showed independent associations (rs8170, hazard ratio (HR) = 1.26, 95% CI 1.17-1.35; rs2363956 HR = 0.84, 95% CI 0.80-0.89). Genotyping these SNPs in 6,800 population-based breast cancer cases and 6,613 controls identified a similar association with estrogen receptor-negative breast cancer (rs2363956 per-allele odds ratio (OR) = 0.83, 95% CI 0.75-0.92, P-trend = 0.0003) and an association with estrogen receptor-positive disease in the opposite direction (OR = 1.07, 95% CI 1.01-1.14, P-trend = 0.016). The five SNPs were also associated with triple-negative breast cancer in a separate study of 2,301 triple-negative cases and 3,949 controls (Ptrend = 1 x 10(-7) to Ptrend = 8 x 10(-5); rs2363956 per-allele OR = 0.80, 95% CI 0.74-0.87, P-trend = 1.1 x 10(-7)).
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Wang, Xianshu
(author)
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Fredericksen, Zachary S.
(author)
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McGuffog, Lesley
(author)
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Tarrell, Robert
(author)
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Sinilnikova, Olga M.
(author)
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Healey, Sue
(author)
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Morrison, Jonathan
(author)
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Kartsonaki, Christiana
(author)
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Lesnick, Timothy
(author)
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Ghoussaini, Maya
(author)
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Barrowdale, Daniel
(author)
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Peock, Susan
(author)
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Cook, Margaret
(author)
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Oliver, Clare
(author)
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Frost, Debra
(author)
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Eccles, Diana
(author)
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Evans, D. Gareth
(author)
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Eeles, Ros
(author)
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Izatt, Louise
(author)
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Chu, Carol
(author)
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Douglas, Fiona
(author)
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Paterson, Joan
(author)
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Stoppa-Lyonnet, Dominique
(author)
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Houdayer, Claude
(author)
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Mazoyer, Sylvie
(author)
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Giraud, Sophie
(author)
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Lasset, Christine
(author)
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Remenieras, Audrey
(author)
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Caron, Olivier
(author)
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Hardouin, Agnes
(author)
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Berthet, Pascaline
(author)
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Hogervorst, Frans B. L.
(author)
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Rookus, Matti A.
(author)
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Jager, Agnes
(author)
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van den Ouweland, Ans
(author)
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Hoogerbrugge, Nicoline
(author)
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van der Luijt, Rob B.
(author)
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Meijers-Heijboer, Hanne
(author)
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Garcia, Encarna B. Gomez
(author)
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Devilee, Peter
(author)
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Vreeswijk, Maaike P. G.
(author)
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Lubinski, Jan
(author)
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Jakubowska, Anna
(author)
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Gronwald, Jacek
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Huzarski, Tomasz
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Byrski, Tomasz
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Gorski, Bohdan
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Cybulski, Cezary
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Spurdle, Amanda B.
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Holland, Helene
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Goldgar, David E.
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John, Esther M.
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Hopper, John L.
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Southey, Melissa
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Buys, Saundra S.
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Daly, Mary B.
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Terry, Mary-Beth
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Schmutzler, Rita K.
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Wappenschmidt, Barbara
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Engel, Christoph
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Meindl, Alfons
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Preisler-Adams, Sabine
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Arnold, Norbert
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Niederacher, Dieter
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Sutter, Christian
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Domchek, Susan M.
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Nathanson, Katherine L.
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Rebbeck, Timothy
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Blum, Joanne L.
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Piedmonte, Marion
(author)
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Rodriguez, Gustavo C.
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Wakeley, Katie
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Boggess, John F.
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Basil, Jack
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Blank, Stephanie V.
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Friedman, Eitan
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Kaufman, Bella
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Laitman, Yael
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Milgrom, Roni
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Andrulis, Irene L.
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Glendon, Gord
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Ozcelik, Hilmi
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Kirchhoff, Tomas
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Vijai, Joseph
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Gaudet, Mia M.
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Altshuler, David
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Guiducci, Candace
(author)
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Loman, NiklasLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-nlo
(author)
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Harbst, KatjaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-kbn
(author)
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Rantala, JohannaKarolinska Institutet
(author)
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Ehrencrona, HansUppsala universitet,Uppsala University,Institutionen för genetik och patologi(Swepub:lu)med-hen
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Gerdes, Anne-Marie
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Thomassen, Mads
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Sunde, Lone
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Peterlongo, Paolo
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Manoukian, Siranoush
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Bonanni, Bernardo
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Viel, Alessandra
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Radice, Paolo
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Caldes, Trinidad
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de la Hoya, Miguel
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Singer, Christian F.
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Fink-Retter, Anneliese
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Greene, Mark H.
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Mai, Phuong L.
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Loud, Jennifer T.
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Guidugli, Lucia
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Lindor, Noralane M.
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Hansen, Thomas V. O.
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Nielsen, Finn C.
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Blanco, Ignacio
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Lazaro, Conxi
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Ramus, Susan J.
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Soucy, Penny
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Rubinstein, Wendy S.
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Arason, Adalgeir
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Rennert, Gad
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Martin, Nicholas G.
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Montgomery, Grant W.
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Chang-Claude, Jenny
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Flesch-Janys, Dieter
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Brauch, Hiltrud
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Severi, Gianluca
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Baglietto, Laura
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Cox, Angela
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Cross, Simon S.
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Miron, Penelope
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Gerty, Sue M.
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Tapper, William
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Yannoukakos, Drakoulis
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Fountzilas, George
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Fasching, Peter A.
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Beckmann, Matthias W.
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Silva, Isabel dos Santos
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Peto, Julian
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Lambrechts, Diether
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Paridaens, Robert
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Ruediger, Thomas
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Foersti, Asta
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Winqvist, Robert
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Pylkaes, Katri
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Diasio, Robert B.
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Lee, Adam M.
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Eckel-Passow, Jeanette
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Vachon, Celine
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Blows, Fiona
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Driver, Kristy
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Dunning, Alison
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Pharoah, Paul P. D.
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Offit, Kenneth
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Pankratz, V. Shane
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Hakonarson, Hakon
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Chenevix-Trench, Georgia
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Easton, Douglas F.
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Couch, Fergus J.
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Bröstcancer-genetikSektion I
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC42:10, s. 885-8921546-17181061-4036
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McGuffog, Lesley
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Tarrell, Robert
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Sinilnikova, Olg ...
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