Development and validation of GFR-estimating equations using diabetes, transplant and weight

Methods. Linear regression was used to relate log-measured GFR (mGFR) to sex, race, diabetes, transplant, weight, various transformations of creatinine and age with and without interactions. Equations were developed in a pooled database of 10 studies [2/3 (N = 5504) for development and 1/3 (N = 2750) for internal validation], and final model selection occurred in 16 additional studies [external validation (N = 3896)]. Results. The mean mGFR was 68, 67 and 68 ml/min/ 1.73 m(2) in the development, internal validation and external validation datasets, respectively. In external validation, an equation that included a linear age term and spline terms in creatinine to account for a reduction in the magnitude of the slope at low serum creatinine values exhibited the best performance (bias = 2.5, RMSE = 0.250) among models using the four basic predictor variables. Addition of terms for diabetes and transplant did not improve performance. Equations with weight showed a small improvement in the subgroup with BMI < 20 kg/m(2). Conclusions. The CKD-EPI equation, based on creatinine, age, sex and race, has been validated and is more accurate than the MDRD study equation. The addition of weight, diabetes and transplant does not significantly improve equation performance.

Schmid, Christopher H. (author)
Zhang, Yaping L. (author)
Coresh, Josef (author)
Manzi, Jane (author)
Landis, Richard (author)
Bakoush, OmranLund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)njur-oba (author)
Contreras, Gabriel (author)
Genuth, Saul (author)
Klintmalm, Goran B. (author)
Poggio, Emilio (author)
Rossing, Peter (author)
Rule, Andrew D. (author)
Weir, Matthew R. (author)
Kusek, John (author)
Greene, Tom (author)
Levey, Andrew S. (author)
NjurmedicinSektion II (creator_code:org_t)

In:Nephrology Dialysis Transplantation: Oxford University Press (OUP)25:2, s. 449-4571460-23850931-0509

By the author/editor: Stevens, Lesley ...; Schmid, Christop ...; Zhang, Yaping L.; Coresh, Josef; Manzi, Jane; Landis, Richard; show more...; Bakoush, Omran; Contreras, Gabri ...; Genuth, Saul; Klintmalm, Goran ...; Poggio, Emilio; Rossing, Peter; Rule, Andrew D.; Weir, Matthew R.; Kusek, John; Greene, Tom; Levey, Andrew S.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

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