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Cancer risk in syst...
Cancer risk in systemic lupus: An updated international multi-centre cohort study
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Bernatsky, Sasha (author)
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Ramsey-Goldman, Rosalind (author)
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Labrecque, Jeremy (author)
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Joseph, Lawrence (author)
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Boivin, Jean-Francois (author)
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Petri, Michelle (author)
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Zoma, Asad (author)
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Manzi, Susan (author)
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Urowitz, Murray B. (author)
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Gladman, Dafna (author)
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Fortin, Paul R. (author)
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Ginzler, Ellen (author)
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Yelin, Edward (author)
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Bae, Sang-Cheol (author)
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Wallace, Daniel J. (author)
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Edworthy, Steven (author)
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Jacobsen, Soren (author)
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Gordon, Caroline (author)
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Dooley, Mary Anne (author)
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Peschken, Christine A. (author)
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Hanly, John G. (author)
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Alarcon, Graciela S. (author)
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- Nived, Ola (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Ruiz-Irastorza, Guillermo (author)
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Isenberg, David (author)
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Rahman, Anisur (author)
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Witte, Torsten (author)
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Aranow, Cynthia (author)
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Kamen, Diane L. (author)
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Steinsson, Kristjan (author)
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Askanase, Anca (author)
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Barr, Susan (author)
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Criswell, Lindsey A. (author)
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- Sturfelt, Gunnar (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Patel, Neha M. (author)
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Senecal, Jean-Luc (author)
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Zummer, Michel (author)
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Pope, Janet E. (author)
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Ensworth, Stephanie (author)
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El-Gabalawy, Hani (author)
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McCarthy, Timothy (author)
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Dreyer, Lene (author)
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Sibley, John (author)
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St Pierre, Ivan (author)
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Clarke, Ann E. (author)
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Journal of Autoimmunity. - : Elsevier BV. - 0896-8411. ; 42, s. 130-135
- Related links:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: To update estimates of cancer risk in SLE relative to the general population. Methods: A multisite international SLE cohort was linked with regional tumor registries. Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected cancers. Results: Across 30 centres, 16,409 patients were observed for 121,283 (average 7.4) person years. In total, 644 cancers occurred. Some cancers, notably hematologic malignancies, were substantially increased (SIR 3.02, 95% confidence interval, CI, 2.48, 3.63), particularly non-Hodgkin's lymphoma, NHL (SIR 4.39, 95% CI 3.46, 5.49) and leukemia. In addition, increased risks of cancer of the vulva (SIR 3.78, 95% CI 1.52, 7.78), lung (SIR 1.30, 95% CI 1.04, 1.60), thyroid (SIR 1.76, 95% CI 1.13, 2.61) and possibly liver (SIR 1.87, 95% CI 0.97, 3.27) were suggested. However, a decreased risk was estimated for breast (SIR 0.73, 95% CI 0.61-0.88), endometrial (SIR 0.44, 95% CI 0.23-0.77), and possibly ovarian cancers (0.64, 95% Cl 0.34-1.10). The variability of comparative rates across different cancers meant that only a small increased risk was estimated across all cancers (SIR 1.14, 95% CI 1.05, 1.23). Conclusion: These data estimate only a small increased risk in SLE (versus the general population) for cancer over-all. However, there is clearly an increased risk of NHL and cancers of the vulva, lung, thyroid, and possibly liver. It remains unclear to what extent the association with NHL is mediated by innate versus exogenous factors. Similarly, the etiology of the decreased breast, endometrial, and possibly ovarian cancer risk is uncertain, though investigations are ongoing. (C) 2013 Elsevier Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Systemic lupus erythematosus
- Epidemiology
- Treatment
- Disease activity
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Bernatsky, Sasha
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Ramsey-Goldman, ...
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Labrecque, Jerem ...
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Joseph, Lawrence
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Boivin, Jean-Fra ...
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Petri, Michelle
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show more...
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Zoma, Asad
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Manzi, Susan
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Urowitz, Murray ...
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Gladman, Dafna
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Fortin, Paul R.
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Ginzler, Ellen
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Yelin, Edward
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Bae, Sang-Cheol
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Wallace, Daniel ...
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Edworthy, Steven
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Jacobsen, Soren
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Gordon, Caroline
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Dooley, Mary Ann ...
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Peschken, Christ ...
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Hanly, John G.
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Alarcon, Graciel ...
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Nived, Ola
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Ruiz-Irastorza, ...
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Isenberg, David
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Rahman, Anisur
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Witte, Torsten
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Aranow, Cynthia
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Kamen, Diane L.
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Steinsson, Krist ...
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Askanase, Anca
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Barr, Susan
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Criswell, Lindse ...
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Sturfelt, Gunnar
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Patel, Neha M.
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Senecal, Jean-Lu ...
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Zummer, Michel
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Pope, Janet E.
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Ensworth, Stepha ...
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El-Gabalawy, Han ...
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McCarthy, Timoth ...
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Dreyer, Lene
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Sibley, John
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St Pierre, Ivan
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Clarke, Ann E.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Journal of Autoi ...
- By the university
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Lund University