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  • Liao, GuangdongSichuan University (author)

Multi-Infection Patterns and Co-infection Preference of 27 Human Papillomavirus Types Among 137,943 Gynecological Outpatients Across China

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-04-07
  • Frontiers Media SA,2020

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  • LIBRIS-ID:oai:lup.lub.lu.se:e580fbca-5578-4898-8356-af5df9c2201a
  • https://lup.lub.lu.se/record/e580fbca-5578-4898-8356-af5df9c2201aURI
  • https://doi.org/10.3389/fonc.2020.00449DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: The epidemiological feature of human papillomavirus (HPV) infection is distinctive in China. We aimed to investigate the multi-infection patterns and co-infection preference of 27 HPV types among gynecological outpatients across China. Methods: Overall 137,943 gynecological outpatients were recruited from eight tertiary hospitals located in seven regions of China, between July 1st, 2014 and December 31st, 2016. The overall, region-specific, age-specific and type-specific prevalence of HPV infection were calculated, respectively. The pattern of HPV infection was also evaluated. Furthermore, rate ratio was calculated to evaluate the co-infection preference of any two HPV genotypes. Results: The overall prevalence of 27 HPVs' [17 high-risk (hr)/10 low-risk (lr)] infection was 23.5%. The age-specific HPV prevalence showed a "U-shaped" pattern. The most prevalent hrHPV genotypes were 16, 52, and 58. Multiple infections were detected in 25.8% of the HPV-positive women, in which dual infection was more prevalent. HPV 16/18 were likely to co-infected with HPV 31 but unlikely with HPV 52/58, i.e., the co-infection of HPV 16 with HPV 31 was high (3.5-fold), but low for HPV 58 (1.8-fold), and 52 (1.2-fold), while the co-infection of HPV 18 with HPV 31 was high (4.3-fold), but low for HPV 52 (1.9-fold), and 58 (1.7-fold). Conclusions: We found age-specific prevalence of HPV infection showed a "U-shaped" pattern for high and low risk HPV, suggesting the importance of screening among younger women and the necessary of detection among older women. We found a novel co-infection preference of HPV 16/18 with 31, 52, and 58, suggesting a need of developing and marketing prophylactic HPV vaccines that protect against more genotypes in China.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Jiang, XiyiHangzhou Medical College, Hangzhou (author)
  • She, BinTellgen Corporation (author)
  • Tang, HuijuanHangzhou Medical College, Hangzhou (author)
  • Wang, ZhongyongThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou (author)
  • Zhou, HongrongChangning Maternity and Infant Health Hospital, Shanghai (author)
  • Ma, YanThe First Affiliated Hospital of University of South China, Hengyang (author)
  • Xu, WeidongSuzhou Municipal Hospital, Suzhou (author)
  • Xu, HongxingSuzhou Municipal Hospital, Suzhou (author)
  • Chen, WenPeking Union Medical College (author)
  • Ji, JianguangLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)med-jji (author)
  • Xi, MingrongSichuan University (author)
  • Chen, TianhuiZhejiang Cancer Hospital,Chinese Academy of Sciences (author)
  • Sichuan UniversityHangzhou Medical College, Hangzhou (creator_code:org_t)

Related titles

  • In:Frontiers in Oncology: Frontiers Media SA102234-943X

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