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Common variants nea...
Common variants near MC4R are associated with fat mass, weight and risk of obesity
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Loos, Ruth J. F. (author)
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Lindgren, Cecilia M. (author)
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Li, Shengxu (author)
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show more...
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Wheeler, Eleanor (author)
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Zhao, Jing Hua (author)
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Prokopenko, Inga (author)
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Inouye, Michael (author)
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Freathy, Rachel M. (author)
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Attwood, Antony P. (author)
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Beckmann, Jacques S. (author)
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Berndt, Sonja I. (author)
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Bergmann, Sven (author)
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Bennett, Amanda J. (author)
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Bingham, Sheila A. (author)
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Bochud, Murielle (author)
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Brown, Morris (author)
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Cauchi, Stephane (author)
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Connell, John M. (author)
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Cooper, Cyrus (author)
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Smith, George Davey (author)
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Day, Ian (author)
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Dina, Christian (author)
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De, Subhajyoti (author)
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Dermitzakis, Emmanouil T. (author)
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Doney, Alex S. F. (author)
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Elliott, Katherine S. (author)
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Elliott, Paul (author)
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Evans, David M. (author)
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Farooqi, I. Sadaf (author)
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Froguel, Philippe (author)
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Ghori, Jilur (author)
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Groves, Christopher J. (author)
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Gwilliam, Rhian (author)
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Hadley, David (author)
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Hall, Alistair S. (author)
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Hattersley, Andrew T. (author)
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Hebebrand, Johannes (author)
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Heid, Iris M. (author)
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Herrera, Blanca (author)
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Hinney, Anke (author)
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Hunt, Sarah E. (author)
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Jarvelin, Marjo-Riitta (author)
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Johnson, Toby (author)
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Jolley, Jennifer D. M. (author)
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Karpe, Fredrik (author)
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Keniry, Andrew (author)
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Khaw, Kay-Tee (author)
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Luben, Robert N. (author)
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- Ridderstråle, Martin (author)
- Lund University,Lunds universitet,Diabetes - klinisk obesitasforskning,Forskargrupper vid Lunds universitet,Diabetes - Clinical Obesity,Lund University Research Groups
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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(creator_code:org_t)
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et al
- 2008-05-04
- 2008
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:6, s. 768-775
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Abstract
Subject headings
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- To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P = 2.8 x 10(-15)) and 5,988 children aged 7-11 (0.13 Z-score units; P = 1.5 x 10(-8)). In case-control analyses (n = 10,583), the odds for severe childhood obesity reached 1.30 (P = 8.0 x 10(-11)). Furthermore, we observed overtransmission of the risk allele to obese offspring in 660 families (P (pedigree disequilibrium test average; PDT-avg) 2.4 x 10(-4)). The SNP location and patterns of phenotypic associations are consistent with effects mediated through altered MC4R function. Our findings establish that common variants near MC4R influence fat mass, weight and obesity risk at the population level and reinforce the need for large-scale data integration to identify variants influencing continuous biomedical traits.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Loos, Ruth J. F.
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Lindgren, Cecili ...
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Li, Shengxu
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Wheeler, Eleanor
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Zhao, Jing Hua
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Prokopenko, Inga
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show more...
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Inouye, Michael
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Freathy, Rachel ...
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Attwood, Antony ...
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Beckmann, Jacque ...
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Berndt, Sonja I.
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Bergmann, Sven
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Bennett, Amanda ...
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Bingham, Sheila ...
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Bochud, Murielle
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Brown, Morris
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Cauchi, Stephane
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Connell, John M.
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Cooper, Cyrus
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Smith, George Da ...
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Day, Ian
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Dina, Christian
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De, Subhajyoti
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Dermitzakis, Emm ...
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Doney, Alex S. F ...
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Elliott, Katheri ...
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Elliott, Paul
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Evans, David M.
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Farooqi, I. Sada ...
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Froguel, Philipp ...
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Ghori, Jilur
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Groves, Christop ...
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Gwilliam, Rhian
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Hadley, David
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Hall, Alistair S ...
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Hattersley, Andr ...
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Hebebrand, Johan ...
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Heid, Iris M.
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Herrera, Blanca
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Hinney, Anke
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Hunt, Sarah E.
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Jarvelin, Marjo- ...
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Johnson, Toby
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Jolley, Jennifer ...
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Karpe, Fredrik
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Keniry, Andrew
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Khaw, Kay-Tee
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Luben, Robert N.
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Ridderstråle, Ma ...
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Groop, Leif
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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Nature Genetics
- By the university
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Lund University