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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00002969naa a2200409 4500
001oai:lup.lub.lu.se:e59b3955-c5e6-46a7-b39b-ad1936329a6f
003SwePub
008160401s2007 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:115700675
024a https://lup.lub.lu.se/record/6929912 URI
024a https://doi.org/10.1111/j.1600-0404.2007.00837.x2 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1157006752 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a H-Stenstam, B.4 aut
2451 0a Neuropathological postmortem evaluation of BNCT for GBM
264 1b Hindawi Limited,c 2007
520 a Background - Thirty patients with glioblastoma multiforme (GBM) were treated by boron neutron capture therapy (BNCT) at the Studsvik facility in Sweden, in a clinical trial exploring a procedure in which 900 mg p-boronophenylalanine (BPA) per kilo body weight was infused in 6 h. Objective - The present study was designed to assess tumor efficacy and radiation damage to the brain for the seven patients in the Studsvik trial that were available for postmortem neuropathological examination. Method - Whole brain slices containing the initial tumor site and other regions showing pathological changes were chosen for microscopy and selected areas were studied by immunological methods. Results - Local control of GBM was observed in all cases. Conclusive evidence for radiation induced brain damage was not found. Conclusion - Using a novel procedure for BPA infusion, BNCT achieves local control of GBM for minimum tumor doses as low as 15 wGy, allowing treatment with very low concomitant doses to surrounding healthy tissues.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a boron neutron capture therapy
653 a glioblastoma multiforme
653 a postmortem
653 a evaluation
700a Pellettieri, L.4 aut
700a Skold, K.4 aut
700a Rezaei, A.4 aut
700a Brun, Arneu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-ab8
710a Tumörmikromiljöb Sektion I4 org
773t Acta Neurologica Scandinavicad : Hindawi Limitedg 116:3, s. 169-176q 116:3<169-176x 1600-0404x 0001-6314
856u http://dx.doi.org/10.1111/j.1600-0404.2007.00837.xy FULLTEXT
8564 8u https://lup.lub.lu.se/record/692991
8564 8u https://doi.org/10.1111/j.1600-0404.2007.00837.x
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:115700675

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H-Stenstam, B.
Pellettieri, L.
Skold, K.
Rezaei, A.
Brun, Arne
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MEDICAL AND HEALTH SCIENCES
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Lund University
Karolinska Institutet

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