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Indirect treatment ...
Indirect treatment comparison of brexucabtagene autoleucel (ZUMA-2) versus standard of care (SCHOLAR-2) in relapsed/refractory mantle cell lymphoma
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- Hess, Georg (author)
- Universitätsmedizin Mainz
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- Dreyling, Martin (author)
- University Hospital Munich
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- Oberic, Lucie (author)
- Toulouse University Hospital
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- Gine, Eva (author)
- Hospital Clínic of Barcelona
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- Zinzani, Pier Luigi (author)
- St. Orsola-Malpighi University Hospital
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- Linton, Kim (author)
- The Manchester Cancer Research Center
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- Vilmar, Adam (author)
- Odense University Hospital
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- Jerkeman, Mats (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Chen, Jenny M.H. (author)
- Precision HEOR
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- Ohler, Anke (author)
- Universitätsmedizin Mainz
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- Stilgenbauer, Stephan (author)
- University of Ulm
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- Thieblemont, Catherine (author)
- Université Paris Cité
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- Lambert, Jonathan (author)
- University College London Hospital
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- Zilioli, Vittorio Ruggero (author)
- Niguarda Hospital
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- Sancho, Juan Manuel (author)
- Hospital Universitari Germans Trias i Pujol
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- Jimenez-Ubieto, Ana (author)
- 12 de Octubre University Hospital
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- Fischer, Luca (author)
- University Hospital Munich
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- Eyre, Toby A. (author)
- Oxford University Hospital
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- Keeping, Sam (author)
- Precision HEOR
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- Park, Julie E. (author)
- Precision HEOR
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- Wu, James J. (author)
- Kite Pharma
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- Nunes, Ana (author)
- Kite Pharma
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- Reitan, John (author)
- RJM Group LLC
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- Wade, Sally W. (author)
- Wade Outcomes Research & Consulting
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- Salles, Gilles (author)
- Memorial Sloan-Kettering Cancer Center
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(creator_code:org_t)
- English.
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In: Leukemia and Lymphoma. - 1042-8194.
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- The SCHOLAR-2 retrospective study highlighted poor overall survival (OS) with standard of care (SOC) regimens among patients with relapsed/refractory (R/R) mantle cell lymphoma (MCL) who failed a covalent Bruton tyrosine kinase inhibitor (BTKi). In the ZUMA-2 single-arm trial, brexucabtagene autoleucel (brexu-cel; autologous anti-CD19 CAR T-cell therapy) demonstrated high rates of durable responses in patients with R/R MCL who had previous BTKi exposure. Here, we compared OS in ZUMA-2 and SCHOLAR-2 using three different methods which adjusted for imbalances in prognostic factors between populations: inverse probability weighting (IPW), regression adjustment (RA), and doubly robust (DR). Brexu-cel was associated with improved OS compared to SOC across all unadjusted and adjusted comparisons. Hazard ratios (95% confidence intervals) were 0.38 (0.23, 0.61) for IPW, 0.45 (0.28, 0.74) for RA, and 0.37 (0.23, 0.59) for DR. These results suggest a substantial survival benefit with brexu-cel versus SOC in patients with R/R MCL after BTKi exposure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- brexucabtagene autoleucel
- CAR T-cell therapy
- indirect treatment comparison
- mantle cell lymphoma
- non-Hodgkin lymphoma
- standard of care
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Hess, Georg
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Dreyling, Martin
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Oberic, Lucie
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Gine, Eva
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Zinzani, Pier Lu ...
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Linton, Kim
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show more...
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Vilmar, Adam
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Jerkeman, Mats
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Chen, Jenny M.H.
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Ohler, Anke
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Stilgenbauer, St ...
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Thieblemont, Cat ...
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Lambert, Jonatha ...
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Zilioli, Vittori ...
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Sancho, Juan Man ...
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Jimenez-Ubieto, ...
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Fischer, Luca
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Eyre, Toby A.
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Keeping, Sam
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Park, Julie E.
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Wu, James J.
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Nunes, Ana
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Reitan, John
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Wade, Sally W.
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Salles, Gilles
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Leukemia and Lym ...
- By the university
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Lund University