Search: onr:"swepub:oai:lup.lub.lu.se:e669f067-e851-434d-9ca5-59b5f41368d6" >
The influence of to...
The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain and plasma amino acids in the rat
-
Holmin, T (author)
-
- Agardh, Carl-David (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
-
Alinder, G (author)
-
show more...
-
Herlin, P (author)
-
Hultberg, B (author)
-
show less...
-
(creator_code:org_t)
- Wiley, 1983
- 1983
- English.
-
In: European Journal of Clinical Investigation. - : Wiley. - 0014-2972 .- 1365-2362. ; 13:3, s. 215-220
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain tissue and plasma amino acids was studied in anaesthetized rats after total hepatectomy. The hepatectomy was performed with the aid of a microsurgical three-stage procedure. In the first stage, division of the inferior vena cava was performed. In the second stage 4 weeks later a porta-caval anastomosis was constructed, followed after 1 week by a total hepatectomy. The brain energy state, defined as the concentrations of phosphocreatine, ATP, ADP and AMP, was unchanged 4 h after the hepatectomy. Plasma amino acids did not differ significantly between hepatectomized and shunted control rats. On the other hand, clear-cut increases in the concentrations of glutamine, and decreases in the concentrations of glutamate and aspartate, were observed in the fronto-parietal part of the cerebral cortex and the brain stem. These changes might explain the minor manifestations of cerebral dysfunction in the early phase of the hepatectomized state.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- labile phosphates
- Hepatectom
- amino acids
- microsurgery
- rat
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database