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  • Toenjes, Anke (author)

Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-09-03
  • Oxford University Press (OUP),2009

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  • LIBRIS-ID:oai:lup.lub.lu.se:e6de07a0-0692-4406-a14f-340d988fcf59
  • https://lup.lub.lu.se/record/1520180URI
  • https://doi.org/10.1093/hmg/ddp423DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Recently, associations of several common genetic variants with height have been reported in different populations. We attempted to identify further variants associated with adult height in a self-contained population (the Sorbs in Eastern Germany) as discovery set. We performed a genome wide association study (GWAS) (similar to 390 000 genetic polymorphisms, Affymetrix gene arrays) on adult height in 929 Sorbian individuals. Subsequently, the best SNPs (P < 0.001) were taken forward to a meta-analysis together with two independent cohorts [Diabetes Genetics Initiative, British 1958 Birth Cohort, (58BC, publicly available)]. Furthermore, we genotyped our best signal for replication in two additional German cohorts (Leipzig, n = 1044 and Berlin, n = 1728). In the primary Sorbian GWAS, we identified 5 loci with a P-value < 10(-5) and 455 SNPs with P-value < 0.001. In the meta-analysis on those 455 SNPs, only two variants in GPR133 (rs1569019 and rs1976930; in LD with each other) retained a P-value at or below 10(-6) and were associated with height in the three cohorts individually. Upon replication, the SNP rs1569019 showed significant effects on height in the Leipzig cohort (P = 0.004, beta = 1.166) and in 577 men of the Berlin cohort (P = 0.049, beta = 1.127) though not in women. The combined analysis of all five cohorts (n = 6,687) resulted in a P-value of 4.7 x 10(-8) (beta = 0.949). In conclusion, our GWAS suggests novel loci influencing height. In view of the robust replication in five different cohorts, we propose GPR133 to be a novel gene associated with adult height.

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  • Koriath, Moritz (author)
  • Schleinitz, Dorit (author)
  • Dietrich, Kerstin (author)
  • Boettcher, Yvonne (author)
  • Rayner, Nigel W. (author)
  • Almgren, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-pal (author)
  • Enigk, Beate (author)
  • Richter, Olaf (author)
  • Rohm, Silvio (author)
  • Fischer-Rosinsky, Antje (author)
  • Pfeiffer, Andreas (author)
  • Hoffmann, Katrin (author)
  • Krohn, Knut (author)
  • Aust, Gabriela (author)
  • Spranger, Joachim (author)
  • Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
  • Blueher, Matthias (author)
  • Kovacs, Peter (author)
  • Stumvoll, Michael (author)
  • Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Human Molecular Genetics: Oxford University Press (OUP)18:23, s. 4662-46680964-69061460-2083

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