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Genetic variation i...
Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-09-03
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Oxford University Press (OUP),2009
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:e6de07a0-0692-4406-a14f-340d988fcf59
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https://lup.lub.lu.se/record/1520180URI
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https://doi.org/10.1093/hmg/ddp423DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Recently, associations of several common genetic variants with height have been reported in different populations. We attempted to identify further variants associated with adult height in a self-contained population (the Sorbs in Eastern Germany) as discovery set. We performed a genome wide association study (GWAS) (similar to 390 000 genetic polymorphisms, Affymetrix gene arrays) on adult height in 929 Sorbian individuals. Subsequently, the best SNPs (P < 0.001) were taken forward to a meta-analysis together with two independent cohorts [Diabetes Genetics Initiative, British 1958 Birth Cohort, (58BC, publicly available)]. Furthermore, we genotyped our best signal for replication in two additional German cohorts (Leipzig, n = 1044 and Berlin, n = 1728). In the primary Sorbian GWAS, we identified 5 loci with a P-value < 10(-5) and 455 SNPs with P-value < 0.001. In the meta-analysis on those 455 SNPs, only two variants in GPR133 (rs1569019 and rs1976930; in LD with each other) retained a P-value at or below 10(-6) and were associated with height in the three cohorts individually. Upon replication, the SNP rs1569019 showed significant effects on height in the Leipzig cohort (P = 0.004, beta = 1.166) and in 577 men of the Berlin cohort (P = 0.049, beta = 1.127) though not in women. The combined analysis of all five cohorts (n = 6,687) resulted in a P-value of 4.7 x 10(-8) (beta = 0.949). In conclusion, our GWAS suggests novel loci influencing height. In view of the robust replication in five different cohorts, we propose GPR133 to be a novel gene associated with adult height.
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Koriath, Moritz
(author)
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Schleinitz, Dorit
(author)
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Dietrich, Kerstin
(author)
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Boettcher, Yvonne
(author)
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Rayner, Nigel W.
(author)
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Almgren, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-pal
(author)
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Enigk, Beate
(author)
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Richter, Olaf
(author)
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Rohm, Silvio
(author)
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Fischer-Rosinsky, Antje
(author)
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Pfeiffer, Andreas
(author)
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Hoffmann, Katrin
(author)
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Krohn, Knut
(author)
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Aust, Gabriela
(author)
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Spranger, Joachim
(author)
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(author)
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Blueher, Matthias
(author)
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Kovacs, Peter
(author)
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Stumvoll, Michael
(author)
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Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Human Molecular Genetics: Oxford University Press (OUP)18:23, s. 4662-46680964-69061460-2083
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Toenjes, Anke
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Koriath, Moritz
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Schleinitz, Dori ...
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Dietrich, Kersti ...
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Boettcher, Yvonn ...
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Rayner, Nigel W.
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Almgren, Peter
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Enigk, Beate
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Richter, Olaf
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Rohm, Silvio
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Fischer-Rosinsky ...
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Pfeiffer, Andrea ...
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Hoffmann, Katrin
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Krohn, Knut
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Aust, Gabriela
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Spranger, Joachi ...
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Groop, Leif
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Blueher, Matthia ...
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Kovacs, Peter
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Stumvoll, Michae ...
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- MEDICAL AND HEALTH SCIENCES
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