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Mild acute cellular...
Mild acute cellular rejection and development of cardiac allograft vasculopathy assessed by intravascular ultrasound and coronary angiography in heart transplant recipients—a SCHEDULE trial substudy
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- Nelson, Lærke Marie (author)
- Copenhagen University Hospital
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- Andreassen, Arne Kristian (author)
- Oslo university hospital
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- Arora, Satish (author)
- Oslo university hospital,University of Oslo
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- Andersson, Bert (author)
- Sahlgrenska University Hospital
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- Gude, Einar (author)
- Oslo university hospital
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- Eiskjær, Hans (author)
- Aarhus University Hospital
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- Rådegran, Göran (author)
- Lund University,Lunds universitet,Lund Hemodynamic Lab,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Dellgren, Göran (author)
- Sahlgrenska University Hospital
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- Gullestad, Lars (author)
- University of Oslo
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- Gustafsson, Finn (author)
- Copenhagen University Hospital,University of Copenhagen
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(creator_code:org_t)
- 2020-02-09
- 2020
- English 12 s.
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In: Transplant International. - : Frontiers Media SA. - 0934-0874 .- 1432-2277. ; 33:5, s. 517-528
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Abstract
Subject headings
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- To evaluate the association between mild acute cellular rejection (ACR) and the development of cardiac allograft vasculopathy (CAV) after heart transplantation (HTx). Substudy of the SCHEDULE trial (n = 115), where de novo HTx recipients were randomized to (i) everolimus with early CNI elimination or (ii) CNI-based immunosuppression. Seventy-six patients (66%) were included based on matched intravascular ultrasound (IVUS) examinations at baseline and year 3 post-HTx. Biopsy-proven ACR within year 1 post-HTx was recorded and graded (1R, 2R, 3R). Development of CAV was assessed by IVUS and coronary angiography at year 3 post-HTx. Median age was 53 years (45–61), and 71% were male. ACR was recorded in 67%, and patients were grouped by rejection profile: no ACR (33%), only 1R (42%), and ≥2R (25%). Median ∆MIT (maximal intimal thickness)BL-3Y was not significantly different between groups (P = 0.84). The incidence of CAV was 49% by IVUS and 26% by coronary angiography with no significant differences between groups. No correlation was found between number of 1R and ∆MITBL-3Y (r = −0.025, P = 0.83). The number of 1R was not a significant predictor of ∆MITBL-3Y (P = 0.58), and no significant interaction with treatment was found (P = 0.98). The burden of mild ACR was not associated with CAV development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- acute cellular rejection
- cardiac allograft vasculopathy
- coronary angiography
- heart transplantation
- intravascular ultrasound
- mild rejection
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Nelson, Lærke Ma ...
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Andreassen, Arne ...
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Arora, Satish
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Andersson, Bert
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Gude, Einar
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Eiskjær, Hans
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show more...
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Rådegran, Göran
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Dellgren, Göran
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Gullestad, Lars
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Gustafsson, Finn
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Transplant Inter ...
- By the university
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Lund University