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Profound impact of sample processing delay on gene expression of multiple myeloma plasma cells.
- Meißner, Tobias (author)
- Seckinger, Anja (author)
-
- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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- Bertsch, Uta (author)
- Haenel, Mathias (author)
- Duering, Jan (author)
- Salwender, Hans (author)
- Goldschmidt, Hartmut (author)
- Morgan, Gareth J (author)
- Hose, Dirk (author)
- Weinhold, Niels (author)
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- (creator_code:org_t)
- 2015-12-30
- 2015
- English.
- In: BMC Medical Genomics. - : Springer Science and Business Media LLC. - 1755-8794. ; 8:1
- Journal article (peer-reviewed)
Abstract
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- Gene expression profiling (GEP) has significantly contributed to the elucidation of the molecular heterogeneity of multiple myeloma plasma cells (MMPC) and only recently it has been recommended for risk stratification. Prior to GEP MMPC need to be enriched resulting in an inability to immediately freeze bone marrow aspirates or use RNA stabilization reagents. As a result in multi-center MM trials sample processing delay due to shipping may be an important confounder of molecular analyses and risk stratification based on GEP data.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- ref (subject category)
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- Meißner, Tobias
- Seckinger, Anja
- Hemminki, Kari
- Bertsch, Uta
- Försti, Asta
- Haenel, Mathias
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- Duering, Jan
- Salwender, Hans
- Goldschmidt, Har ...
- Morgan, Gareth J
- Hose, Dirk
- Weinhold, Niels
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