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Cellular architectu...
Cellular architecture of human brain metastases
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- Gonzalez, Hugo (author)
- University of California, San Francisco
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- Mei, Wenbin (author)
- University of California, San Francisco
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- Robles, Isabella (author)
- University of California, San Francisco
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- Hagerling, Catharina (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,University of California, San Francisco
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- Allen, Breanna M. (author)
- University of California, San Francisco
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- Hauge Okholm, Trine Line (author)
- University of California, San Francisco
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- Nanjaraj, Ankitha (author)
- University of California, San Francisco
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- Verbeek, Tamara (author)
- University of California, San Francisco
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- Kalavacherla, Sandhya (author)
- University of California, San Francisco
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- van Gogh, Merel (author)
- University of California, San Francisco
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- Georgiou, Stephen (author)
- University of California, San Francisco
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- Daras, Mariza (author)
- University of California, San Francisco
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- Phillips, Joanna J. (author)
- UCSF Helen Diller Family Comprehensive Cancer Center,University of California, San Francisco
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- Spitzer, Matthew H. (author)
- University of California, San Francisco,UCSF Helen Diller Family Comprehensive Cancer Center
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- Roose, Jeroen P. (author)
- University of California, San Francisco
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- Werb, Zena (author)
- UCSF Helen Diller Family Comprehensive Cancer Center,University of California, San Francisco
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Cell. - : Elsevier BV. - 0092-8674. ; 185:4, s. 20-745
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Abstract
Subject headings
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- Brain metastasis (BrM) is the most common form of brain cancer, characterized by neurologic disability and an abysmal prognosis. Unfortunately, our understanding of the biology underlying human BrMs remains rudimentary. Here, we present an integrative analysis of >100,000 malignant and non-malignant cells from 15 human parenchymal BrMs, generated by single-cell transcriptomics, mass cytometry, and complemented with mouse model- and in silico approaches. We interrogated the composition of BrM niches, molecularly defined the blood-tumor interface, and revealed stromal immunosuppressive states enriched with infiltrated T cells and macrophages. Specific single-cell interrogation of metastatic tumor cells provides a framework of 8 functional cell programs that coexist or anticorrelate. Collectively, these programs delineate two functional BrM archetypes, one proliferative and the other inflammatory, that are evidently shaped through tumor-immune interactions. Our resource provides a foundation to understand the molecular basis of BrM in patients with tumor cell-intrinsic and host environmental traits.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- blood tumor barrier
- CyTOF
- human metastasis
- metastasis-associated macrophages
- metastasis-infiltrated T cells
- metastatic niche
- metastatic program
- metastatic tumor cells
- metastatic tumors
- single cell
Publication and Content Type
- art (subject category)
- ref (subject category)
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Cell
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To the university's database
- By the author/editor
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Gonzalez, Hugo
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Mei, Wenbin
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Robles, Isabella
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Hagerling, Catha ...
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Allen, Breanna M ...
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Hauge Okholm, Tr ...
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show more...
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Nanjaraj, Ankith ...
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Verbeek, Tamara
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Kalavacherla, Sa ...
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van Gogh, Merel
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Georgiou, Stephe ...
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Daras, Mariza
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Phillips, Joanna ...
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Spitzer, Matthew ...
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Roose, Jeroen P.
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Werb, Zena
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cell
- By the university
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Lund University