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Convergence of chro...
Convergence of chromogranin and amyloid metabolism in the brain.
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- Johansson, Per (author)
- Skaraborg Hospital
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- Mattsson, Niklas (author)
- Sahlgrenska Academy
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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Wallin, A. (author)
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Johansson, J.-O. (author)
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Andreasson, U. (author)
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Andersen, O (author)
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Haghighi, S. (author)
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Olsson, M. (author)
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Stridsberg, M (author)
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Svensson, J. (author)
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Blennow, K. (author)
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Zetterberg, H. (author)
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(creator_code:org_t)
- 2010-07
- 2010
- English.
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In: Alzheimer's & Dementia. - : Wiley. - 1552-5279 .- 1552-5260. ; 6:4, s. 511-511
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Abstract
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- Background: Much is unknown regarding the regulation of amyloid precursor protein (APP) processing in the human central nervous system. It has been hypothesized that amyloidogenic APP-processing preferentially occurs in the regulated secretory pathway of neurons. To test this hypothesis we looked for correlations of APP-derived molecules in CSF with chromogranin (Cg) derived peptides, representing the regulated secretion. Methods: Patients with Alzheimer's disease (AD, N = 32), multiple sclerosis (MS, N = 50) and healthy controls (N = 70) were enrolled. CSF was analyzed for the amyloid peptides Aβ1-42, Aβx-42, Aβx-40, Aβx-38, α-cleaved soluble APP (α-sAPP), β-cleaved soluble APP (β-sAPP), and peptides derived from CgB and SgII (Secretogranin-II, CgC). We investigated CSF levels of the protease BACE1, which processes APP into Aβ, in relation to Cg-levels. Finally, we measured Cg levels in cell media from untreated and BACE1-inhibited SH-SY5Y human neuroblastoma cells. Results: CSF Cg levels correlated to sAPP and Aβ peptides in AD, MS and controls, and to CSF BACE1. Cell medium from BACE1-inhibited cells had decreased CgB levels. Conclusions: These results suggest that a large part of APP in the human central nervous system is processed in the regulated secretory pathway of neurons.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- kon (subject category)
- ref (subject category)
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- By the author/editor
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Johansson, Per
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Mattsson, Niklas
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Hansson, Oskar
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Wallin, A.
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Johansson, J.-O.
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Andreasson, U.
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show more...
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Andersen, O
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Haghighi, S.
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Olsson, M.
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Stridsberg, M
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Svensson, J.
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Blennow, K.
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Zetterberg, H.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's & De ...
- By the university
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Lund University