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Search: onr:"swepub:oai:lup.lub.lu.se:e7bcbd70-d5dc-4ebd-9eda-fdecc5187dc2" > Preeclampsia is Ass...

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  • Masoumi, ZahraLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine (author)

Preeclampsia is Associated with Sex-Specific Transcriptional and Proteomic Changes in Fetal Erythroid Cells

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-04-25
  • MDPI AG,2019

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:e7bcbd70-d5dc-4ebd-9eda-fdecc5187dc2
  • https://lup.lub.lu.se/record/e7bcbd70-d5dc-4ebd-9eda-fdecc5187dc2URI
  • https://doi.org/10.3390/ijms20082038DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Preeclampsia (PE) has been associated with placental dysfunction, resulting in fetal hypoxia, accelerated erythropoiesis, and increased erythroblast count in the umbilical cord blood (UCB). Although the detailed effects remain unknown, placental dysfunction can also cause inflammation, nutritional, and oxidative stress in the fetus that can affect erythropoiesis. Here, we compared the expression of surface adhesion molecules and the erythroid differentiation capacity of UCB hematopoietic stem/progenitor cells (HSPCs), UCB erythroid profiles along with the transcriptome and proteome of these cells between male and female fetuses from PE and normotensive pregnancies. While no significant differences were observed in UCB HSPC migration/homing and in vitro erythroid colony differentiation, the UCB HSPC transcriptome and the proteomic profile of the in vitro differentiated erythroid cells differed between PE vs. normotensive samples. Accordingly, despite the absence of significant differences in the UCB erythroid populations in male or female fetuses from PE or normotensive pregnancies, transcriptional changes were observed during erythropoiesis, particularly affecting male fetuses. Pathway analysis suggested deregulation in the mammalian target of rapamycin complex 1/AMP-activated protein kinase (mTORC1/AMPK) signaling pathways controlling cell cycle, differentiation, and protein synthesis. These results associate PE with transcriptional and proteomic changes in fetal HSPCs and erythroid cells that may underlie the higher erythroblast count in the UCB in PE.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Maes, Gregory E.University Hospitals Leuven,Catholic University of Leuven (author)
  • Herten, KoenUniversity Hospitals Leuven,Catholic University of Leuven (author)
  • Cortés-Calabuig, ÁlvaroUniversity Hospitals Leuven (author)
  • Alattar, Abdul GhaniLund University,Lunds universitet,Stamceller till röda blodkroppar,Forskargrupper vid Lunds universitet,Transfusionsmedicin,Stem Cells to Red Blood Cells,Lund University Research Groups,Transfusion Medicine(Swepub:lu)med-a_a (author)
  • Hanson, EvaLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)mphy-eha (author)
  • Erlandsson, LenaLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-leo (author)
  • Mezey, EvaNational Institute of Dental and Craniofacial Research(Swepub:lu)astr-eme (author)
  • Magnusson, MattiasLund University,Lunds universitet,Stamceller och cancerstamcellsreglering,Forskargrupper vid Lunds universitet,Stem cell and Cancer stem cell Regulation,Lund University Research Groups(Swepub:lu)molm-mma (author)
  • Vermeesch, Joris R.Catholic University of Leuven,University Hospitals Leuven (author)
  • Familari, MaryUniversity of Melbourne(Swepub:lu)med-myf (author)
  • Hansson, Stefan R.Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)gyn-sha (author)
  • Obstetrik och gynekologi, LundSektion V (creator_code:org_t)

Related titles

  • In:International Journal of Molecular Sciences: MDPI AG20:81422-0067

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