Search: onr:"swepub:oai:lup.lub.lu.se:e8093bf7-a6cb-46e1-a6aa-cfe8c800d233" >
Use of Vascular Ass...
Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes : The SUMMIT VIP Study
-
- Shore, Angela C (author)
- University of Exeter
-
- Colhoun, Helen M (author)
- University of Edinburgh
-
- Natali, Andrea (author)
- University of Pisa
-
show more...
-
- Palombo, Carlo (author)
- University of Pisa
-
- Khan, Faisel (author)
- University of Dundee
-
- Östling, Gerd (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
-
- Aizawa, Kunihiko (author)
- University of Exeter
-
- Kennbäck, Cecilia (author)
- Lund University
-
- Casanova, Francesco (author)
- University of Exeter
-
- Persson, Margaretha (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
-
- Gooding, Kim (author)
- University of Exeter
-
- Gates, Phillip E (author)
- University of Exeter
-
- Looker, Helen (author)
- University of Dundee
-
- Dove, Fiona (author)
- University of Dundee
-
- Belch, Jill (author)
- University of Dundee
-
- Pinnola, Silvia (author)
- University of Pisa
-
- Venturi, Elena (author)
- University of Pisa
-
- Kozakova, Michaela (author)
- University of Pisa
-
- Goncalves, Isabel (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - translationella studier,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Cardiovascular Research - Translational Studies
-
- Kravic, Jasmina (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Diabetiska komplikationer,Translational Muscle Research,Lund University Research Groups,Diabetic Complications
-
- Björkbacka, Harry (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Cardiovascular Research - Cellular Metabolism and Inflammation
-
- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
-
show less...
-
(creator_code:org_t)
-
- 2018-07-30
- 2018
- English 8 s.
-
In: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 41:10, s. 2212-2219
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://care.diabete...
-
https://lup.lub.lu.s...
-
https://doi.org/10.2...
-
show less...
Abstract
Subject headings
Close
- OBJECTIVE: Cardiovascular disease (CVD) risk prediction represents an increasing clinical challenge in the treatment of diabetes. We used a panel of vascular imaging, functional assessments, and biomarkers reflecting different disease mechanisms to identify clinically useful markers of risk for cardiovascular (CV) events in subjects with type 2 diabetes (T2D) with or without manifest CVD.RESEARCH DESIGN AND METHODS: The study cohort consisted of 936 subjects with T2D recruited at four European centers. Carotid intima-media thickness and plaque area, ankle-brachial pressure index, arterial stiffness, endothelial function, and circulating biomarkers were analyzed at baseline, and CV events were monitored during a 3-year follow-up period.RESULTS: The CV event rate in subjects with T2D was higher in those with (n = 440) than in those without (n = 496) manifest CVD at baseline (5.53 vs. 2.15/100 life-years, P < 0.0001). New CV events in subjects with T2D with manifest CVD were associated with higher baseline levels of inflammatory biomarkers (interleukin 6, chemokine ligand 3, pentraxin 3, and hs-CRP) and endothelial mitogens (hepatocyte growth factor and vascular endothelial growth factor A), whereas CV events in subjects with T2D without manifest CVD were associated with more severe baseline atherosclerosis (median carotid plaque area 30.4 mm2 [16.1-92.2] vs. 19.5 mm2 [9.5-40.5], P = 0.01). Conventional risk factors, as well as measurements of arterial stiffness and endothelial reactivity, were not associated with CV events.CONCLUSIONS: Our observations demonstrate that markers of inflammation and endothelial stress reflect CV risk in subjects with T2D with manifest CVD, whereas the risk for CV events in subjects with T2D without manifest CVD is primarily related to the severity of atherosclerosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Shore, Angela C
-
Colhoun, Helen M
-
Natali, Andrea
-
Palombo, Carlo
-
Khan, Faisel
-
Östling, Gerd
-
show more...
-
Aizawa, Kunihiko
-
Kennbäck, Cecili ...
-
Casanova, France ...
-
Persson, Margare ...
-
Gooding, Kim
-
Gates, Phillip E
-
Looker, Helen
-
Dove, Fiona
-
Belch, Jill
-
Pinnola, Silvia
-
Venturi, Elena
-
Kozakova, Michae ...
-
Goncalves, Isabe ...
-
Kravic, Jasmina
-
Björkbacka, Harr ...
-
Nilsson, Jan
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Diabetes Care
- By the university
-
Lund University