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- Andersen, Claus Yding (author)
Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- Elsevier BV,2011
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:e88436bf-fa43-47ae-861f-08b0937c2545
- https://lup.lub.lu.se/record/2594759URI
- https://doi.org/10.1016/j.rbmo.2011.04.003DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Using data from a large prospective randomized controlled trial that evaluated the effect of recombinant LH (rLH) co-administration for ovarian stimulation, the present study assessed whether progesterone concentration on the day of human chorionic gonadotrophin (HCG) administration was associated with pregnancy outcome. Progesterone concentration was measured on stimulation day 1 and on the day of HCG administration in 475 patients who underwent IVF/intracytoplasmic sperm injection treatment following ovarian stimulation with gonadotrophin-releasing hormone (GnRH) agonist and recombinant FSH with or without rLH administration from day 6 of stimulation. There was no significant association between the late-follicular-phase progesterone concentration and the clinical pregnancy rate. However, progesterone concentration was strongly associated with the number of follicles and retrieved oocytes. Late-follicular-phase LH concentration also showed a significant positive association with progesterone concentration (P = 0.018). Administration of rLH during ovarian stimulation did not affect progesterone concentration. The present study does not support an association between progesterone concentration on the day of HCG administration and the probability of clinical pregnancy in women undergoing ovarian stimulation with GnRH agonists and gonadotrophins for assisted reproduction treatment. Instead, late-follicular-phase progesterone concentration appears to be governed by the number of preovulatory follicles and LH concentration. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
- ovarian stimulation
- pregnancy outcome
- progesterone elevation
Added entries (persons, corporate bodies, meetings, titles ...)
- Bungum, LeifLund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups(Swepub:lu)med-lbu (author)
- Andersen, Anders Nyboe (author)
- Humaidan, Peter (author)
- Reproduktionsmedicin, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:Reproductive BioMedicine Online: Elsevier BV23:2, s. 187-1951472-64911472-6483
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