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Vitamin B6 cataboli...
Vitamin B6 catabolism and lung cancer risk : Results from the Lung Cancer Cohort Consortium (LC3)
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- Zuo, H. (author)
- University of Bergen
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- Ueland, P. M. (author)
- University of Bergen,Haukeland University Hospital,Bevital AS,Fred Hutchinson Cancer Research Center
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- Tell, G. S. (author)
- University of Bergen,University of Paris-Saclay,Human Genetics Foundation (HuGeF)
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- Fanidi, A. (author)
- University of Cambridge,International Agency for Research on Cancer, World Health Organization
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- Zheng, W. (author)
- Vanderbilt University
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- Shu, X. (author)
- Vanderbilt University
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- Xiang, Y. (author)
- Renji Hospital
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- Wu, J. (author)
- Vanderbilt University
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- Prentice, R. (author)
- Fred Hutchinson Cancer Research Center
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- Pettinger, M. (author)
- Fred Hutchinson Cancer Research Center
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- Thomson, C. A. (author)
- University of Arizona
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- Giles, G. G. (author)
- University of Melbourne,Cancer Council Victoria,National Cancer Institute, USA
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- Hodge, A. (author)
- Cancer Council Victoria,University of Melbourne
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- Cai, Q. (author)
- Vanderbilt University
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- Blot, W. J. (author)
- Vanderbilt University
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- Johansson, Mikael (author)
- Umeå universitet,Umeå University,Onkologi
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- Hultdin, Johan (author)
- Umeå universitet,Umeå University,Klinisk kemi
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- Grankvist, Kjell (author)
- Umeå universitet,Umeå University,Klinisk kemi
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- Stevens, V. L. (author)
- American Cancer Society
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- McCullough, M. L. (author)
- American Cancer Society
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- Weinstein, S. J. (author)
- National Cancer Institute, USA
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- Albanes, D. (author)
- National Cancer Institute, USA
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- Ziegler, R. G. (author)
- National Cancer Institute, USA
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- Freedman, N. D. (author)
- National Cancer Institute, USA
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- Caporaso, N. E. (author)
- National Cancer Institute, USA
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- Langhammer, A. (author)
- Norwegian University of Science and Technology
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- Hveem, K. (author)
- Norwegian University of Science and Technology
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- Næss, M. (author)
- Norwegian University of Science and Technology
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- Buring, J. E. (author)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
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- Lee, I. (author)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
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- Gaziano, J. M. (author)
- Boston Veteran's Administration (VA) Healthcare,Brigham and Women's Hospital / Harvard Medical School,Harvard University
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- Severi, G. (author)
- University of Paris-Saclay,Human Genetics Foundation (HuGeF)
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- Zhang, X. (author)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
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- Stampfer, M. J. (author)
- Brigham and Women's Hospital / Harvard Medical School,Harvard University
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- Han, J. (author)
- Indiana University
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- Zeleniuch-Jacquotte, A. (author)
- New York University
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- Marchand, L. L. (author)
- University of Hawai'i at Hilo
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- Yuan, J. (author)
- University of Pittsburgh Medical Center
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- Wang, R. (author)
- University of Pittsburgh Medical Center
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- Koh, W. (author)
- National University of Singapore
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- Gao, Y. (author)
- Shanghai Jiao Tong University
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- Ericson, U. (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Visvanathan, K. (author)
- Johns Hopkins University School of Medicine
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- Jones, M. R. (author)
- Johns Hopkins University
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- Relton, C. (author)
- University of Bristol,University of Newcastle upon Tyne
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- Brennan, P. (author)
- International Agency for Research on Cancer, World Health Organization
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- Johansson, M. (author)
- International Agency for Research on Cancer, World Health Organization
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- Ulvik, A. (author)
- Bevital AS
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English 8 s.
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In: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 30:3, s. 478-485
- Related links:
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http://dx.doi.org/10...
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http://www.annalsofo...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Background Increased vitamin B6 catabolism related to inflammation, as measured by the PAr index (the ratio of 4-pyridoxic acid over the sum of pyridoxal and pyridoxal-5'-phosphate), has been positively associated with lung cancer risk in two prospective European studies. However, the extent to which this association translates to more diverse populations is not known. Materials and methods For this study, we included 5323 incident lung cancer cases and 5323 controls individually matched by age, sex, and smoking status within each of 20 prospective cohorts from the Lung Cancer Cohort Consortium. Cohort-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between PAr and lung cancer risk were calculated using conditional logistic regression and pooled using random-effects models. Results PAr was positively associated with lung cancer risk in a dose-response fashion. Comparing the fourth versus first quartiles of PAr resulted in an OR of 1.38 (95% CI: 1.19-1.59) for overall lung cancer risk. The association between PAr and lung cancer risk was most prominent in former smokers (OR: 1.69, 95% CI: 1.36-2.10), men (OR: 1.60, 95% CI: 1.28-2.00), and for cancers diagnosed within 3 years of blood draw (OR: 1.73, 95% CI: 1.34-2.23). Conclusion Based on pre-diagnostic data from 20 cohorts across 4 continents, this study confirms that increased vitamin B6 catabolism related to inflammation and immune activation is associated with a higher risk of developing lung cancer. Moreover, PAr may be a pre-diagnostic marker of lung cancer rather than a causal factor.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- inflammation
- lung cancer
- Lung Cancer Cohort Consortium
- nested case-control study
- PAr
- vitamin B6
- PAr
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
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Zuo, H.
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Ueland, P. M.
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Tell, G. S.
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Fanidi, A.
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Zheng, W.
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Shu, X.
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show more...
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Xiang, Y.
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Wu, J.
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Prentice, R.
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Pettinger, M.
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Thomson, C. A.
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Giles, G. G.
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Hodge, A.
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Cai, Q.
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Blot, W. J.
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Johansson, Mikae ...
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Hultdin, Johan
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Grankvist, Kjell
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Stevens, V. L.
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McCullough, M. L ...
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Weinstein, S. J.
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Albanes, D.
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Ziegler, R. G.
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Freedman, N. D.
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Caporaso, N. E.
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Langhammer, A.
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Hveem, K.
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Næss, M.
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Buring, J. E.
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Lee, I.
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Gaziano, J. M.
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Severi, G.
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Zhang, X.
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Stampfer, M. J.
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Han, J.
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Zeleniuch-Jacquo ...
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Marchand, L. L.
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Yuan, J.
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Wang, R.
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Koh, W.
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Gao, Y.
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Ericson, U.
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Visvanathan, K.
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Jones, M. R.
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Relton, C.
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Brennan, P.
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Johansson, M.
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Ulvik, A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Annals of Oncolo ...
- By the university
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Lund University
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Umeå University