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Alpha-Synuclein Rep...
Alpha-Synuclein Repeat Variants and Survival in Parkinson's Disease
- Article/chapterEnglish2014
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LIBRIS-ID:oai:lup.lub.lu.se:e956cbb6-27b2-4b6b-b665-4b9a84b62883
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https://lup.lub.lu.se/record/4662569URI
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https://doi.org/10.1002/mds.25841DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:129547395URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Objectives: To determine whether alpha-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). Conclusions: In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in PD. Further studies of alpha-synuclein's role in disease progression and long-term outcomes are needed. (C) 2014 International Parkinson and Movement Disorder Society
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Biernacka, Joanna M.
(author)
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Armasu, Sebastian M.
(author)
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Anderson, Kari
(author)
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Frigerio, Roberta
(author)
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Aasly, Jan O.
(author)
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Annesi, Grazia
(author)
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Bentivoglio, Anna Rita
(author)
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Brighina, Laura
(author)
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Chartier-Harlin, Marie-Christine
(author)
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Goldwurm, Stefano
(author)
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Hadjigeorgiou, Georgios
(author)
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Jasinska-Myga, Barbara
(author)
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Jeon, Beom Seok
(author)
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Kim, Yun Joong
(author)
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Krueger, Rejko
(author)
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Lesage, Suzanne
(author)
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Markopoulou, Katerina
(author)
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Mellick, George
(author)
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Morrison, Karen E.
(author)
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Puschmann, AndreasLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-aps
(author)
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Tan, Eng-King
(author)
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Crosiers, David
(author)
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Theuns, Jessie
(author)
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Van Broeckhoven, Christine
(author)
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Wirdefeldt, KarinKarolinska Institutet
(author)
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Wszolek, Zbigniew K.
(author)
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Elbaz, Alexis
(author)
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Maraganore, Demetrius M.
(author)
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Neurologi, LundSektion IV
(creator_code:org_t)
Related titles
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In:Movement Disorders: Wiley29:8, s. 1053-10570885-3185
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In:Movement disorders : official journal of the Movement Disorder Society: Wiley29:8, s. 1053-10571531-8257
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Chung, Sun Ju
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Biernacka, Joann ...
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Armasu, Sebastia ...
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Anderson, Kari
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Frigerio, Robert ...
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Aasly, Jan O.
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Annesi, Grazia
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Bentivoglio, Ann ...
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Brighina, Laura
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Chartier-Harlin, ...
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Goldwurm, Stefan ...
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Hadjigeorgiou, G ...
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Jasinska-Myga, B ...
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Jeon, Beom Seok
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Kim, Yun Joong
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Krueger, Rejko
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Lesage, Suzanne
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Markopoulou, Kat ...
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Mellick, George
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Morrison, Karen ...
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Puschmann, Andre ...
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Tan, Eng-King
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Crosiers, David
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Theuns, Jessie
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Van Broeckhoven, ...
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Wirdefeldt, Kari ...
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Wszolek, Zbignie ...
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Elbaz, Alexis
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Maraganore, Deme ...
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Karolinska Institutet