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Loss of Function of...
Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity
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Asai, Masato (author)
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Ramachandrappa, Shwetha (author)
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Joachim, Maria (author)
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Shen, Yuan (author)
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Zhang, Rong (author)
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Nuthalapati, Nikhil (author)
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Ramanathan, Visali (author)
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Strochlic, David E. (author)
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Ferket, Peter (author)
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Linhart, Kirsten (author)
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Ho, Caroline (author)
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Novoselova, Tatiana V. (author)
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Garg, Sumedha (author)
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- Ridderstråle, Martin (author)
- Lund University,Lunds universitet,Diabetes - klinisk obesitasforskning,Forskargrupper vid Lunds universitet,Diabetes - Clinical Obesity,Lund University Research Groups
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- Marcus, Claude (author)
- Karolinska Institutet
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Hirschhorn, Joel N. (author)
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Keogh, Julia M. (author)
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O'Rahilly, Stephen (author)
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Chan, Li F. (author)
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Clark, Adrian J. (author)
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Farooqi, I. Sadaf (author)
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Majzoub, Joseph A. (author)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2013
- 2013
- English.
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In: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 341:6143, s. 275-278
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Abstract
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- Melanocortin receptor accessory proteins (MRAPs) modulate signaling of melanocortin receptors in vitro. To investigate the physiological role of brain-expressed melanocortin 2 receptor accessory protein 2 (MRAP2), we characterized mice with whole-body and brain-specific targeted deletion of Mrap2, both of which develop severe obesity at a young age. Mrap2 interacts directly with melanocortin 4 receptor (Mc4r), a protein previously implicated in mammalian obesity, and it enhances Mc4r-mediated generation of the second messenger cyclic adenosine monophosphate, suggesting that alterations in Mc4r signaling may be one mechanism underlying the association between Mrap2 disruption and obesity. In a study of humans with severe, early-onset obesity, we found four rare, potentially pathogenic genetic variants in MRAP2, suggesting that the gene may also contribute to body weight regulation in humans.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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- By the author/editor
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Asai, Masato
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Ramachandrappa, ...
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Joachim, Maria
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Shen, Yuan
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Zhang, Rong
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Nuthalapati, Nik ...
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show more...
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Ramanathan, Visa ...
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Strochlic, David ...
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Ferket, Peter
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Linhart, Kirsten
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Ho, Caroline
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Novoselova, Tati ...
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Garg, Sumedha
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Ridderstråle, Ma ...
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Marcus, Claude
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Hirschhorn, Joel ...
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Keogh, Julia M.
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O'Rahilly, Steph ...
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Chan, Li F.
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Clark, Adrian J.
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Farooqi, I. Sada ...
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Majzoub, Joseph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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Science
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Lund University
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Karolinska Institutet