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Metal Exposure and ...
Metal Exposure and SNCA rs356219 Polymorphism Associated With Parkinson Disease and Parkinsonism
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- Lucchini, Roberto G. (author)
- Florida International University,University of Brescia
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- Guazzetti, Stefano (author)
- Azienda USL-IRCCS di Reggio Emilia
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- Renzetti, Stefano (author)
- University of Brescia
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- Broberg, Karin (author)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups
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- Caci, Margherita (author)
- University of Brescia
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- Covolo, Loredana (author)
- University of Brescia
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- Crippa, Patrizia (author)
- Ancelle della Carità, Brescia
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- Gelatti, Umberto (author)
- University of Brescia
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- Hashim, Dana (author)
- Icahn School of Medicine at Mount Sinai
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- Oppini, Manuela (author)
- University of Brescia
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- Pepe, Fulvio (author)
- Fondazione Poliambulanza Istituto Ospedaliero, Brescia
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- Pilotto, Andrea (author)
- University of Brescia,Ospedale Sant'Isidoro di Trescore Balneario, Bergamo
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- Passeri, Chiara (author)
- University of Brescia
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- Placidi, Donatella (author)
- University of Brescia
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- Rizzetti, Maira Cristina (author)
- Ospedale Sant'Isidoro di Trescore Balneario, Bergamo
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- Turla, Marinella (author)
- ASST Della Valcamonica
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- Wahlberg, Karin (author)
- Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups
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- Padovani, Alessandro (author)
- University of Brescia
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(creator_code:org_t)
- 2020-12-09
- 2020
- English.
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In: Frontiers in Neurology. - : Frontiers Media SA. - 1664-2295. ; 11
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Abstract
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- Objective: In the province of Brescia, Italy, historical neurotoxic metal exposure has occurred for several decades. This study aimed to explore the role of metal exposure and genetics on Parkinson's Disease (PD) and Parkinsonism. Methods: Cases were enrolled from four local clinics for movement disorders. Randomly selected controls non-affected by neurological or psychiatric conditions were enrolled from the same health centers keeping a similar gender ratio and age distribution as for cases. Data on sociodemographic variables, clinical onset and life habits were collected besides accurate occupational and residential history. Blood samples were collected from all participants for genotyping of target polymorphisms in genes linked to PD and/or metal transport. Results: A total number of 432 cases and 444 controls were enrolled in the study, with average age of 71 years (72.2 for cases and 70 for controls). The average age at diagnosis was 65.9 years (SD 9.9). Among the potential risk factors, family history of PD or Parkinsonism showed the strongest association with the diseases (OR = 4.2, 95% CI 2.3, 7.6 on PD; OR = 4.3, 95% CI 1.9, 9.5 for Parkinsonism), followed by polymorphism rs356219 in the alpha-synuclein (SNCA) gene (OR = 2.03, 95% CI 1.3, 3.3 for CC vs. TT on PD; OR = 2.5, 95% CI 1.1, 5.3 for CC vs. TT on Parkinsonism), exposure to metals (OR = 2.4;, 95% CI 1.3, 4.2 on PD), being born in a farm (OR = 1.8; 95% CI 1.1, 2.8 on PD; OR = 2.6; 95% CI 1.4, 4.9 on Parkinsonism) and being born in the province of Brescia (OR = 1.7; 95% CI 1.0, 2.9 on PD). Conditional OR of having PD depending by SNCA polymorphism and metal exposure highlights higher risk of PD among CC SNCA carriers and being exposed to metals. However, the interaction term was not statistically significant. Conclusions: Lifetime exposure to metals and genetic variation in SNCA gene are relevant determinants of PD and Parkinsonism in the highly industrialized area of Brescia, Italy. The lack of evidence of statistical interaction between environmental and genetic factors may be due to the low frequencies of subjects representing the exposure categories and the polymorphism variants and does not rule out the biological interaction.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- manganese
- metal exposure
- occupational exposure
- parkinson disease
- parkinsonism
- SNCA gene
Publication and Content Type
- art (subject category)
- ref (subject category)
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Lucchini, Robert ...
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Guazzetti, Stefa ...
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Renzetti, Stefan ...
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Broberg, Karin
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Caci, Margherita
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Covolo, Loredana
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Crippa, Patrizia
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Gelatti, Umberto
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Hashim, Dana
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Oppini, Manuela
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Pepe, Fulvio
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Pilotto, Andrea
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Passeri, Chiara
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Placidi, Donatel ...
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Rizzetti, Maira ...
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Turla, Marinella
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Wahlberg, Karin
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Padovani, Alessa ...
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Frontiers in Neu ...
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Lund University
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Karolinska Institutet