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Stochastic aspects ...
Stochastic aspects of transmitter release and bioenergetic dysfunction in isolated nerve terminals
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- Nicholls, David (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Biochemical Society Transactions. - 1470-8752 .- 0300-5127. ; 38, s. 457-459
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Synaptosomes (isolated nerve terminals) have been studied for more than 40 years. The preparation allows aspects of transmitter metabolism and release to be studied ex vivo from specific brain regions of animals of any age. Conditions can be devised to enable the terminals to fire spontaneous action potentials, allowing the presynaptic control of glutamate exocytosis to be studied. Recent developments have greatly increased the sensitivity with which the bioenergetics of the intra-synaptosomal mitochondria can be investigated.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- exocytosis
- brain
- potassium channel
- glutamate
- synaptosome
Publication and Content Type
- kon (subject category)
- ref (subject category)
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