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Factors associated ...
Factors associated with health-related quality of life among adults with tetralogy of Fallot
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- Sandström, Anette (author)
- Umeå universitet,Umeå University,Avdelningen för medicin,Umeå Univ, Heart Ctr, Umeå, Sweden;Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden
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- Sandberg, Camilla (author)
- Umeå universitet,Umeå University,Avdelningen för medicin,Umeå Univ, Heart Ctr, Umeå, Sweden;Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden
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- Rinnström, Daniel, 1982- (author)
- Umeå universitet,Umeå University,Avdelningen för medicin,Umeå Univ, Heart Ctr, Umeå, Sweden;Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden
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- Engström, Karl Gunnar (author)
- Umeå universitet,Umeå University,Avdelningen för medicin,Umeå Univ, Heart Ctr, Umeå, Sweden;Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden
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- Dellborg, Mikael, 1954 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Thilén, Ulf (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Cardiol Clin Sci, Lund, Sweden
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- Sörensson, Peder (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
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- Nielsen, Niels Erik (author)
- Linköpings universitet,Linköping University,Linköping Univ, Dept Med & Hlth Sci, Linköping, Sweden,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Christersson, Christina (author)
- Uppsala universitet,Uppsala University,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden
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- Johansson, Bengt (author)
- Umeå universitet,Umeå University,Avdelningen för medicin,Umeå Univ, Heart Ctr, Umeå, Sweden;Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden
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(creator_code:org_t)
- 2019-02-27
- 2019
- English.
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In: Open Heart. - : BMJ. - 2053-3624. ; 6:1
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Abstract
Subject headings
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- Background Due to improved care, the numbers of patients with tetralogy of Fallot (ToF) are increasing. However, long-term morbidity and need for reinterventions are concerns and also address issues of quality of life (QoL). Methods Patients with ToF and valid EuroQol-5 dimensions questionnaire (EQ-5D) were identified in the national Swedish register on congenital heart disease. EQ-5D index was calculated and dichotomised into best possible health-related QoL (EQ-5D index =1) or differed from 1. Results 288 patients met the criteria and were analysed. Univariate logistic regression showed a positive association between New York Heart Association (NYHA) class I (OR 8.32, 95% CI 3.80 to 18.21), physical activity >3 h/week (OR 3.34, 95% CI 1.67 to 6.66) and a better right ventricular function (OR 2.56, 95% CI 1.09 to 6.02). A negative association between symptoms (OR 0.23, 95% CI 0.13 to 0.42), cardiovascular medication (OR 0.31, 95% CI 0.18 to 0.53), age (OR 0.97, 95% CI 0.96 to 0.99) and EQ-5D index was observed. In multivariate logistic regression, NYHA I (OR 7.28, 95% CI 3.29 to 16.12) and physical activity >3 h/week (OR 2.27, 95% CI 1.07 to 4.84) remained associated with best possible health-related QoL. Replacing NYHA with symptoms in the model yielded similar results. Conclusion In this registry study, self-reported physical activity, staff-reported NYHA class and absence of symptoms were strongly associated with best possible health-related QoL measured by EQ-5D. Physical activity level is a potential target for intervention to improve QoL in this population but randomised trials are needed to test such a hypothesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- congenital heart disease
- physical activity
- quality of life
- register
- tetralogy of fallot
Publication and Content Type
- art (subject category)
- ref (subject category)
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Open Heart
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Sandström, Anett ...
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Sandberg, Camill ...
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Rinnström, Danie ...
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Engström, Karl G ...
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Dellborg, Mikael ...
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Thilén, Ulf
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Sörensson, Peder
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Nielsen, Niels E ...
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Christersson, Ch ...
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Johansson, Bengt
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Open Heart
- By the university
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Lund University
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Umeå University
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Uppsala University
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Karolinska Institutet
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Linköping University
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University of Gothenburg