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Prevalence of IgA-a...
Prevalence of IgA-antiendomysium and IgA-antigliadin autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children and adolescents
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- Carlsson, Annelie (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pediatrisk autoimmunitet,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Pediatric Autoimmunity,Lund University Research Groups
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- Axelsson, Irene E. M. (author)
- Sahlgrenska University Hospital
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- Borulf, Stefan K. (author)
- Sahlgrenska University Hospital
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- Bredberg, Anders C. A. (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine
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- Lindberg, Bengt A. (author)
- Sahlgrenska University Hospital
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- Sjöberg, Klas G. (author)
- Ystad Hospital
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- Ivarsson, Sten-A. (author)
- Sahlgrenska University Hospital
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(creator_code:org_t)
- 1999-06-01
- 1999
- English 5 s.
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In: Pediatrics. - : American Academy of Pediatrics (AAP). - 1098-4275 .- 0031-4005. ; 103:6 I, s. 1248-1252
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Abstract
Subject headings
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- Objective. This study was conducted to investigate the prevalence of celiac disease (CD) in children and adolescents at diagnosis of insulin- dependent diabetes mellitus (IDDM) before insulin treatment was started. Material and Methods. At diagnosis of IDDM, and before treatment was started, 115 children and adolescents were screened for IgA-antiendomysium (EMA) and IgA-antigliadin antibodies (AGA). Those found to be EMA-positive and/or AGA- positive were investigated further with intestinal biopsy. Results. Of the 115 patients, 2 had known CD at diagnosis of IDDM; of the remainder of patients, 6% (7/113) were found to be EMA-positive and 9% (10/113) were found to have AGA levels above normal. Of the 6 patients who underwent biopsy, 5 manifested villous atrophy. In addition, 2 patients with high EMA and AGA antibody titers refused biopsy, and 4 patients with low EMA and/or AGA titers were found to have normal titers at control before biopsy decision. Conclusion. Because the prevalence of CD at diagnosis of IDDM would seem to be 6% to 8%, screening for CD seems to be justified among patients with newly diagnosed IDDM.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Celiac disease
- IgA-antiendomysium antibodies
- IgA-antigliadin antibodies
- Insulin-dependent diabetes mellitus
- autoantibody
- gliadin antibody
- immunoglobulin A antibody
- adolescent
- allele
- antibody specificity
- antibody titer
- article
- celiac disease
- child
- female
- human
- immune system
- immunoregulation
- insulin dependent diabetes mellitus
- insulin treatment
- major clinical study
- male
- priority journal
Publication and Content Type
- art (subject category)
- ref (subject category)
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