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Prevalence of IgA-a...
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Carlsson, AnnelieLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pediatrisk autoimmunitet,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Pediatric Autoimmunity,Lund University Research Groups
(author)
Prevalence of IgA-antiendomysium and IgA-antigliadin autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children and adolescents
- Article/chapterEnglish1999
Publisher, publication year, extent ...
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1999-06-01
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American Academy of Pediatrics (AAP),1999
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5 s.
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LIBRIS-ID:oai:lup.lub.lu.se:ebf98a47-dd27-43c5-9ed5-9331954be5df
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https://lup.lub.lu.se/record/ebf98a47-dd27-43c5-9ed5-9331954be5dfURI
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https://doi.org/10.1542/peds.103.6.1248DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Objective. This study was conducted to investigate the prevalence of celiac disease (CD) in children and adolescents at diagnosis of insulin- dependent diabetes mellitus (IDDM) before insulin treatment was started. Material and Methods. At diagnosis of IDDM, and before treatment was started, 115 children and adolescents were screened for IgA-antiendomysium (EMA) and IgA-antigliadin antibodies (AGA). Those found to be EMA-positive and/or AGA- positive were investigated further with intestinal biopsy. Results. Of the 115 patients, 2 had known CD at diagnosis of IDDM; of the remainder of patients, 6% (7/113) were found to be EMA-positive and 9% (10/113) were found to have AGA levels above normal. Of the 6 patients who underwent biopsy, 5 manifested villous atrophy. In addition, 2 patients with high EMA and AGA antibody titers refused biopsy, and 4 patients with low EMA and/or AGA titers were found to have normal titers at control before biopsy decision. Conclusion. Because the prevalence of CD at diagnosis of IDDM would seem to be 6% to 8%, screening for CD seems to be justified among patients with newly diagnosed IDDM.
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Axelsson, Irene E. M.Sahlgrenska University Hospital(Swepub:lu)pedi-iax
(author)
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Borulf, Stefan K.Sahlgrenska University Hospital(Swepub:lu)pedi-sbo
(author)
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Bredberg, Anders C. A.Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mikr-abr
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Lindberg, Bengt A.Sahlgrenska University Hospital(Swepub:lu)pedi-bli
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Sjöberg, Klas G.Ystad Hospital(Swepub:lu)medf-ksj
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Ivarsson, Sten-A.Sahlgrenska University Hospital(Swepub:lu)pedi-siv
(author)
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Pediatrik, LundSektion V
(creator_code:org_t)
Related titles
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In:Pediatrics: American Academy of Pediatrics (AAP)103:6 I, s. 1248-12521098-42750031-4005
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