Prevalence of IgA-antiendomysium and IgA-antigliadin autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children and adolescents

Carlsson, AnnelieLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pediatrisk autoimmunitet,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Pediatric Autoimmunity,Lund University Research Groups (author)

Objective. This study was conducted to investigate the prevalence of celiac disease (CD) in children and adolescents at diagnosis of insulin- dependent diabetes mellitus (IDDM) before insulin treatment was started. Material and Methods. At diagnosis of IDDM, and before treatment was started, 115 children and adolescents were screened for IgA-antiendomysium (EMA) and IgA-antigliadin antibodies (AGA). Those found to be EMA-positive and/or AGA- positive were investigated further with intestinal biopsy. Results. Of the 115 patients, 2 had known CD at diagnosis of IDDM; of the remainder of patients, 6% (7/113) were found to be EMA-positive and 9% (10/113) were found to have AGA levels above normal. Of the 6 patients who underwent biopsy, 5 manifested villous atrophy. In addition, 2 patients with high EMA and AGA antibody titers refused biopsy, and 4 patients with low EMA and/or AGA titers were found to have normal titers at control before biopsy decision. Conclusion. Because the prevalence of CD at diagnosis of IDDM would seem to be 6% to 8%, screening for CD seems to be justified among patients with newly diagnosed IDDM.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
Celiac disease
IgA-antiendomysium antibodies
IgA-antigliadin antibodies
Insulin-dependent diabetes mellitus
autoantibody
gliadin antibody
immunoglobulin A antibody
adolescent
allele
antibody specificity
antibody titer
article
celiac disease
child
female
human
immune system
immunoregulation
insulin dependent diabetes mellitus
insulin treatment
major clinical study
male
priority journal

Axelsson, Irene E. M.Sahlgrenska University Hospital(Swepub:lu)pedi-iax (author)
Borulf, Stefan K.Sahlgrenska University Hospital(Swepub:lu)pedi-sbo (author)
Bredberg, Anders C. A.Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mikr-abr (author)
Lindberg, Bengt A.Sahlgrenska University Hospital(Swepub:lu)pedi-bli (author)
Sjöberg, Klas G.Ystad Hospital(Swepub:lu)medf-ksj (author)
Ivarsson, Sten-A.Sahlgrenska University Hospital(Swepub:lu)pedi-siv (author)
Pediatrik, LundSektion V (creator_code:org_t)

In:Pediatrics: American Academy of Pediatrics (AAP)103:6 I, s. 1248-12521098-42750031-4005

By the author/editor: Carlsson, Anneli ...; Axelsson, Irene ...; Borulf, Stefan K ...; Bredberg, Anders ...; Lindberg, Bengt ...; Sjöberg, Klas G.; show more...; Ivarsson, Sten-A ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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