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Effects of naloxone...
Effects of naloxone on c-jun/AP-1 in MET-enkephalin- and FMRFamide-immunoreactive neurons of a gastropod snail
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- Dyakonova, V (author)
- P.N. Lebedev Physical Institute of the Russian Academy of Sciences
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- Elofsson, Rolf (author)
- Lund University,Lunds universitet,Funktionell zoologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Functional zoology,Department of Biology,Faculty of Science
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- Carlberg, M (author)
- Lund University
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- Sakharov, D A (author)
- P.N. Lebedev Physical Institute of the Russian Academy of Sciences
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PN. Lebedev Physical Institute of the Russian Academy of Sciences Funktionell zoologi (creator_code:org_t)
- 1999
- 1999
- English.
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In: Acta Biologica Hungarica. - 0236-5383. ; 50:1-3, s. 43-54
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Abstract
Subject headings
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- 1. Opioid- and FMRFamide (FMRFa)-ergic systems are believed to play antagonistic behavioral roles in both higher and lower animals. In our previous experiments on a snail, behavioral choice has been demonstrated to be dependent on a balance between FMRFa and enkephalins [7]. Here, we examined if the disturbance of the balance causes changes in the activity of both systems. Opiate receptor blocker naloxone was applied and its effect on c-jun expression of met-enkephalin (MEnk)- and FMRFa-ergic neurons was examined immunocytochemically in terrestrial gastropod snail Cepaea nemoralis. 2. In control, untreated snails, central neurons with c-jun/AP-1-like-immunoreactivity were found to occur. These included MEnk-, FMRFa- and 5HT-immunoreactive (-ir) neurons, as was revealed by double-labelling. 3. After treatment with naloxone for 4 h, the following changes were observed: (i) increase in the number of MEnk-ir neurons; increase in the number of neurons showing c-jun/AP-1 and MEnk double-labeling; (ii) disappearance of c-jun/AP-1-immunoreactivity from some FMRFa-ir neurons. 4. It is suggested that immediate early genes are involved in the mechanisms responsible for the reciprocal regulation of the opioid and antiopioid neuropeptide systems.
Subject headings
- NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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