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A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy : A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking
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- Colvill, Emma (author)
- University of Sydney,Royal North Shore Hospital
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- Booth, Jeremy (author)
- Royal North Shore Hospital,University of Sydney
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- Nill, Simeon (author)
- Institute of Cancer Research London
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- Elsevier BV, 2016
- 2016
- English 7 s.
- In: Radiotherapy and Oncology. - : Elsevier BV. - 0167-8140. ; 119:1, s. 159-165
- Journal article (peer-reviewed)
Abstract
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- Purpose A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive radiotherapy in the presence of patient-measured tumor motion. Methods and materials Ten institutions with robotic(2), gimbaled(2), MLC(4) or couch tracking(2) used common materials including CT and structure sets, motion traces and planning protocols to create a lung and a prostate plan. For each motion trace, the plan was delivered twice to a moving dosimeter; with and without real-time adaptation. Each measurement was compared to a static measurement and the percentage of failed points for γ-tests recorded. Results For all lung traces all measurement sets show improved dose accuracy with a mean 2%/2 mm γ-fail rate of 1.6% with adaptation and 15.2% without adaptation (p < 0.001). For all prostate the mean 2%/2 mm γ-fail rate was 1.4% with adaptation and 17.3% without adaptation (p < 0.001). The difference between the four systems was small with an average 2%/2 mm γ-fail rate of <3% for all systems with adaptation for lung and prostate. Conclusions The investigated systems all accounted for realistic tumor motion accurately and performed to a similar high standard, with real-time adaptation significantly outperforming non-adaptive delivery methods.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering (hsv//eng)
Keyword
- Couch tracking
- Gimbaled tracking
- MLC tracking
- Organ motion
- Robotic tracking
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- art (subject category)
- ref (subject category)
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- Colvill, Emma
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