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AMPKβ isoform expre...
AMPKβ isoform expression patterns in various adipocyte models and in relation to body mass index
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- Kopietz, Franziska (author)
- Lund University,Lunds universitet,Glukostransport och proteintrafficking,Forskargrupper vid Lunds universitet,Proteinfosforylering,Glucose Transport and Protein Trafficking,Lund University Research Groups,Protein Phosphorylation
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- Degerman, Eva (author)
- Lund University,Lunds universitet,Signaltransduktionsforskning,Forskargrupper vid Lunds universitet,Insulin Signal Transduction,Lund University Research Groups
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- Göransson, Olga (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Proteinfosforylering,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Protein Phosphorylation,Lund University Research Groups
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(creator_code:org_t)
- 2022-08-04
- 2022
- English.
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In: Frontiers in Physiology. - : Frontiers Media SA. - 1664-042X. ; 13
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Abstract
Subject headings
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- AMP-activated protein kinase (AMPK) activation is considered a useful strategy for the treatment of type 2 diabetes (T2D). It is unclear whether the expression and/or activity of AMPK in adipocytes is dysregulated in obesity. Also, the expression/activity pattern of AMPKβ isoforms, which are targets for AMPK activators, in adipocytes remains elusive. In this study we show that the two AMPKβ isoforms make roughly equal contributions to AMPK activity in primary human and mouse adipocytes, whereas in cultured 3T3-L1 adipocytes of mouse origin and in primary rat adipocytes, β1-associated activity clearly dominates. Additionally, we found that obesity is not associated with changes in AMPK subunit expression or kinase activity in adipocytes isolated from subcutaneous adipose tissue from individuals with various BMI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- adipocytes
- AMPKβ
- expression
- human
- kinase activity
- obesity
Publication and Content Type
- art (subject category)
- ref (subject category)
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