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Dietary Phosphorus,...
Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis : The DIET-HD Study
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- Su, Guobin (author)
- Karolinska Institutet,Karolinska Institute,Guangdong Provincial Hospital of Traditional Chinese Medicine
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- Saglimbene, Valeria (author)
- University of Bari Aldo Moro,University of Sydney
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- Wong, Germaine (author)
- University of Sydney
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Bernier-Jean, Amélie (author)
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- Carrero, Juan Jesus (author)
- Karolinska Institutet,Karolinska Institute
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- Natale, Patrizia (author)
- University of Sydney,University of Foggia,University of Bari Aldo Moro
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- Ruospo, Marinella (author)
- University of Bari Aldo Moro
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- Hegbrant, Jorgen (author)
- Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Craig, Jonathan C. (author)
- Flinders University
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- Strippoli, Giovanni F.M. (author)
- University of Bari Aldo Moro,University of Sydney
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(creator_code:org_t)
- 2022-09-30
- 2022
- English.
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In: Nutrients. - : MDPI AG. - 2072-6643. ; 14:19
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Abstract
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- Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained within the DIET-HD study in 8110 adults on haemodialysis. Adjusted Cox regression analyses were conducted to evaluate the association between the total and source-specific phosphorus (plant-, animal-, or processed and other sources) with mortality. During a median 3.8 years of follow-up, there were 2953 deaths, 1160 cardiovascular-related. The median phosphorus intake was 1388 mg/day. Every standard deviation (SD) (896 mg/day) increase in total phosphorus was associated with higher all-cause mortality [hazard ratio (HR), 1.16; 95% confidence intervals (CI), 1.06–1.26] and cardiovascular mortality (HR, 1.18; 95% CI, 1.03–1.36). Every SD (17%) increase in the proportion of phosphorus from plant sources was associated with lower all-cause mortality (HR, 0.95; 95% CI, 0.90–0.99). Every SD (9%) increase in the proportion of phosphorus from the processed and other sources was associated with higher all-cause mortality (HR, 1.06; 95% CI, 1.02–1.10). A higher total phosphorus intake was associated with increased all-cause and cardiovascular death. This association is driven largely by the phosphorus intake from processed food. Plant based phosphorus was associated with lower all-cause mortality.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- cohort
- DIET-HD
- haemodialysis
- mortality
- phosphorus
- plant-base
Publication and Content Type
- art (subject category)
- ref (subject category)
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Nutrients
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- By the author/editor
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Su, Guobin
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Saglimbene, Vale ...
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Wong, Germaine
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Bernier-Jean, Am ...
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Carrero, Juan Je ...
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Natale, Patrizia
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Ruospo, Marinell ...
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Hegbrant, Jorgen
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Craig, Jonathan ...
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Strippoli, Giova ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Nutrients
- By the university
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Lund University
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Karolinska Institutet