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Search: onr:"swepub:oai:lup.lub.lu.se:eed7e1c7-afd7-44b7-a3df-7943e0baf6d5" > Pyrimethanil and ch...

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  • Giffin, AndrewNorth Carolina State University (author)

Pyrimethanil and chlorpyrifos air concentrations and pregnant women's urinary metabolites in the Infants’ Environmental Health Study (ISA), Costa Rica

  • Article/chapterEnglish2022

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  • Elsevier BV,2022

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  • LIBRIS-ID:oai:lup.lub.lu.se:eed7e1c7-afd7-44b7-a3df-7943e0baf6d5
  • https://lup.lub.lu.se/record/eed7e1c7-afd7-44b7-a3df-7943e0baf6d5URI
  • https://doi.org/10.1016/j.envint.2022.107328DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

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  • Background: Only few studies have compared environmental pesticide air concentrations with specific urinary metabolites to evaluate pathways of exposure. Therefore, we compared pyrimethanil and chlorpyrifos concentrations in air with urinary 4-hydroxypyrimethanil (OHP, metabolite of pyrimethanil) and 3,5,6-trichloro-2-pyridinol (TCPy, metabolite of chlorpyrifos) among pregnant women from the Infant's Environmental Health Study (ISA) in Matina County, Costa Rica. Methods: During pregnancy, we obtained repeat urinary samples from 448 women enrolled in the ISA study. We extrapolated pyrimethanil and chlorpyrifos concentrations measured with passive air samplers (PAS) (n = 48, from 12 schools), across space and time using a Bayesian spatiotemporal model. We subsequently compared these concentrations with urinary OHP and TCPy in 915 samples from 448 women, using separate mixed models and considering several covariables. Results: A 10% increase in air pyrimethanil (ng/m3) was associated with a 5.7% (95% confidence interval (CI 4.6, 6.8) increase in OHP (μg/L). Women living further from banana plantations had lower OHP: −0.7% (95% CI −1.2, −0.3) for each 10% increase in distance (meters) as well as women who ate rice and beans ≥15 times a week −23% (95% CI −38, −4). In addition, each 1 ng/m3 increase in chlorpyrifos in air was associated with a 1.5% (95% CI 0.2, 2.8) increase in TCPy (μg/L), and women working in agriculture tended to have increased TCPy (21%, 95% CI −2, 49). Conclusion: The Bayesian spatiotemporal models were useful to estimate pyrimethanil and chlorpyrifos air concentrations across space and time. Our results suggest inhalation of pyrimethanil and chlorpyrifos is a pathway of environmental exposure. PAS seems a useful technique to monitor environmental current-use pesticide exposures. For future studies, we recommend increasing the number of locations of environmental air measurements, obtaining all air and urine measurements during the same month, and, ideally, including dermal exposure estimates as well.

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  • Hoppin, Jane A.North Carolina State University (author)
  • Córdoba, LeonelNational University Of Costa Rica (author)
  • Solano-Díaz, KarlaNational University Of Costa Rica (author)
  • Ruepert, ClemensNational University Of Costa Rica (author)
  • Peñaloza-Castañeda, JorgeNational University Of Costa Rica (author)
  • Lindh, ChristianLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups(Swepub:lu)ymed-cli (author)
  • Reich, Brian J.North Carolina State University (author)
  • van Wendel de Joode, BernaNational University Of Costa Rica (author)
  • North Carolina State UniversityNational University Of Costa Rica (creator_code:org_t)

Related titles

  • In:Environment International: Elsevier BV1660160-4120

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