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Treatment according...
Treatment according to guidelines may bridge the gender gap in outcome for patients with stage T1 urinary bladder cancer
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- Sjöström, Carin (author)
- Karolinska Institute,Capio St Gorans Hosp, Dept Surg, Sect Urol, Sankt Goransplan 1, SE-11281 Stockholm, Sweden;Karolinska Inst, Dept Mol Med & Surg, Sect Urol, Stockholm, Sweden
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- Thorstenson, Andreas (author)
- Karolinska Institute,Capio St Gorans Hosp, Dept Surg, Sect Urol, Sankt Goransplan 1, SE-11281 Stockholm, Sweden;Karolinska Inst, Dept Mol Med & Surg, Sect Urol, Stockholm, Sweden
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- Ströck, Viveka (author)
- Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Urol, Gothenburg, Sweden
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- Hosseini-Aliabad, Abolfazl (author)
- Karolinska University Hospital,Karolinska Univ Hosp, Dept Urol, Stockholm, Sweden
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- Aljabery, Firas (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland
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- Liedberg, Fredrik (author)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Skåne University Hospital,Lund Univ, Dept Translat Med, Malmo, Sweden;Skane Univ Hosp, Dept Urol, Malmo, Sweden
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- Sherif, Amir (author)
- Umeå universitet,Umeå University,Urologi och andrologi,Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden
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- Malmström, Per-Uno (author)
- Uppsala universitet,Urologkirurgi,Uppsala University Hospital,Akad Univ Hosp, Sweden
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- Rosell, Johan (author)
- Linköpings universitet,Linköping University,Linkoping Univ, Reg Canc Ctr South East Sweden, Linkoping, Sweden;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Regionalt Cancercentrum
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- Gårdmark, Truls (author)
- Karolinska Institutet,Danderyd Hospital,Danderyd Hosp, Sweden; Karolinska Inst, Sweden
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- Jahnson, Staffan (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland
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(creator_code:org_t)
- 2018-04-20
- 2018
- English.
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In: Scandinavian Journal of Urology. - : Medical Journals Sweden AB. - 2168-1805 .- 2168-1813. ; 52:3, s. 186-193
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Abstract
Subject headings
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- Objective: The aim of this investigation was to study differences between male and female patients with stage T1 urinary bladder cancer (UBC) regarding intravesical instillation therapy, second resection and survival. Materials and methods: This study included all patients with non-metastatic primary T1 UBC reported to the Swedish National Register of Urinary Bladder Cancer (SNRUBC) from 1997 to 2014, excluding those treated with primary cystectomy. Differences between groups were evaluated using chi-squared tests and logistic regression, and survival was investigated using Kaplan–Meier and log-rank tests and Cox proportional hazards analysis. Results: In all, 7681 patients with T1 UBC (77% male, 23% female) were included. Females were older than males at the time of diagnosis (median age at presentation 76 and 74 years, respectively; p < .001). A larger proportion of males than females underwent intravesical instillation therapy (39% vs 33%, p < .001). Relative survival was lower in women aged ≥75 years and women with G3 tumours compared to men. However, women aged ≥75 years who had T1G3 tumours and underwent second resection followed by intravesical instillation therapy showed a relative survival equal to that observed in men. Conclusions: This population-based study demonstrates that women of all ages with T1 UBC undergo intravesical instillation therapy less frequently than men, and that relative survival is poorer in women aged ≥75 years than in men of the same age when intravesical instillation therapy and second resection are not used. However, these disparities may disappear with treatment according to guidelines.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Bladder cancer
- female
- gender
- intravesical instillation therapy
- male
- population-based
- survival
- Bladder cancer
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Sjöström, Carin
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Thorstenson, And ...
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Ströck, Viveka
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Hosseini-Aliabad ...
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Aljabery, Firas
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Liedberg, Fredri ...
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show more...
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Sherif, Amir
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Malmström, Per-U ...
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Rosell, Johan
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Gårdmark, Truls
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Jahnson, Staffan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Scandinavian Jou ...
- By the university
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Lund University
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Umeå University
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Uppsala University
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Karolinska Institutet
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Linköping University